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Stroke Research and Treatment
Volume 2017 (2017), Article ID 2371956, 6 pages
Research Article

Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value

1Department of Neurology, Neurocritical Care, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, Turkey
2Department of Neurology, Neuroscience Research Center (NSRC), Imam-Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Neurology, Cerebrovascular Disease, Eskisehir Osmangazi University, Eskisehir, Turkey
4Department of Biostatistics, Eskisehir Osmangazi University, Eskisehir, Turkey

Correspondence should be addressed to Elyar Sadeghi-Hokmabadi

Received 23 July 2016; Revised 3 December 2016; Accepted 14 December 2016; Published 3 January 2017

Academic Editor: Wai-Kwong Tang

Copyright © 2017 Elyar Sadeghi-Hokmabadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. This study was set to assess the effect of renal dysfunction on outcome of stroke patients treated with intravenous thrombolysis (IVT). Methods. This multicenter research involved 403 patients from January 2009 to March 2015. Patients were divided into two groups: (1) control group with GFR ≥ 45 mL/min/1.73 m2 and (2) low GFR group with GFR < 45 mL/min/1.73 m2. Outcome measurements were poor outcome (mRS 3–6) and mortality at 3 months and symptomatic intracerebral hemorrhage (SICH) within the first 24–36 hours. Univariate and multivariate regression analyses were performed, and odds ratios (ORs) were determined at 95% confidence intervals (CIs). Results. Univariate analyses determined that every decrease of GFR by 10 mL/min/1.73 m2 significantly increased the risk of poor outcome (OR 1.19, 95% CI 1.09–1.30, ) and mortality (OR 1.18, 95% CI 1.06–1.32, ). In multivariate regression, adjusted for all variables with value < 0.1, low GFR (GFR < 45 versus GFR equal to or more than 45) was associated with poor outcome (OR adjusted 2.15, 95% CI 1.01–4.56, ). Conclusion. In IVT for acute stroke, renal dysfunction with GFR < 45 mL/min/1.73 m2 before treatment determined increased odds for poor outcome compared to GFR of more than 45 mL/min/1.73 m2.