Determining the Joint Effect of Obesity and Diabetes on All-Cause Mortality and Cardiovascular-Related Mortality following an Ischemic Stroke

Table 1

Variables and definitions of prespecified variables and potential confounders for analysis.

Variables	Definition
Pre-Specified Variables
Age †	< 65 years, ≥ 65 years
Gender †	Male, Female
Race/ethnicity †	non-Hispanic White, non-Hispanic Black,; Hispanic, Asian, Other
Treatment assignment †	Aspirin + extended release dipyridamole/telmisartan, Clopidogrel/telmisartan, Aspirin + extended release dipyridamole/placebo, Clopidogrel/placebo
Qualifying stroke neurological severity †	Mild (NIHSS < 8),; Moderate/Severe (NIHSS ≥ 8)
Ischemic stroke sub-type †	Large-artery atherosclerosis, Cardioembolism,; Small-artery occlusion, Other, Undetermined
Potential Confounders
Baseline systolic blood pressure †	in mmHg
History of previous stroke or TIA †	Yes, No
History of previous myocardial infarction †	Yes, No
History of atrial fibrillation	Yes, No
History of congestive heart failure	Yes, No
History of coronary artery disease †	Yes, No
History of hypertension †	Yes, No
History of hyperlipidemia †	Yes, No
Smoking status †	Current smoker, Former/Never smoker
Regular alcohol consumption	At least 1 drink/week, No alcohol consumption
Average physical activity prior to qualifying stroke †	Sedentary: walking <1 mile/day, Some physical activity: 20-30 minutes, 3 times/week, Intense physical activity: > 30 minutes, > 3 times/week

indicates potential confounder for all-cause mortality; † indicates potential confounder for cardiovascular-related mortality.