Brain injury of diverse etiologies is frequently encountered in the clinical setting and requires diverse management. Transient global ischemic brain injury may result from cardiac arrest where cerebral perfusion diminishes to the point that blood supply can no longer meet the metabolic demand of brain or from aneurysmal subarachnoid hemorrhage where bleed from an intracranial aneurysm elevates the intracranial pressure above the blood pressure leading to at least momentary perfusion arrest. How different or similar the mechanisms of these two brain injuries and their management are and whether they can be grouped together is the focus of this special issue.

We invite our peers to submit original research and review articles that seek to define the mechanisms of brain injury after transient global cerebral ischemic stroke and aneurysmal subarachnoid hemorrhage (aSAH). We are especially interested in articles that explore gender differences, search for specific biomarkers, and identify new therapeutic targets in humans as well as in animal models. Potential include, but are not limited to:

• Early brain injury after global ischemic stroke and aSAH
• Role of inflammation and oxidative stress in brain injury
• Search for biomarkers; how similar or different they be for these stroke subtypes
• Identification of new therapeutic targets
• Similarity and differences in early (at admission) management and therapeutic options of global ischemic stroke and aSAH
• New modification of existing animal models to study brain injury after global ischemic stroke and aSAH
• Gender differences in global ischemic stroke and aSAH
• Findings from recently completed clinical trials for global ischemic stroke and aSAH

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/srt/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/srt/injury/ according to the following timetable: