Therapeutic hypothermia is a promising neuroprotective intervention shown to improve outcome from brain ischemia in humans. Ample research indicates that it is a robust protectant in various animal models of acute neurological injury. Translation into clinical practice has only been convincingly demonstrated to improve neurological outcome after cardiac arrest and neonatal hypoxia-ischemia. Applying hypothermia to stroke patients is fraught with logistical and methodological challenges. This issue will focus on the state of therapeutic hypothermia, its applications, its pathophysiological mechanisms of protection, and its potential for future clinical use in stroke. Manuscripts of original research and review topics are welcome.

The topics to be covered include, but are not limited to:

• Effective cooling methods in patients (endovascular, surface, pharmacological, etc.)
• Cooling challenges in stroke patients
• Therapeutic hypothermia in patients with ischemic and hemorrhagic stroke, subarachnoid hemorrhage, and pediatric stroke
• Prevention of hyperthermia or maintenance of normothermia
• Molecular and cellular mechanisms underlying hypothermic protection
• Future strategies for cooling and combination therapy
• Optimal application of cooling (timing, duration, etc.)

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/srt/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: