Table of Contents
SRX Pharmacology
Volume 2010, Article ID 485146, 8 pages
http://dx.doi.org/10.3814/2010/485146
Research Article

Comparison of Postprandial Responses to a High-Fat Meal in Hypertriglyceridemic Men and Women before and after Treatment with Fenofibrate in the Genetics and Lipid Lowering Drugs and Diet Network (GOLDN) Study

1Department of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, AL 35294-1150, USA
2Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL 35294-1150, USA
3Department of Laboratory Medicine and Pathology, University of Minnesota, MN 55455-0213, USA
4Lipid Metabolism Laboratory, Tufts University, MA 02155, USA
5Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, MN 55455-0213, USA

Received 26 October 2009; Accepted 24 November 2009

Copyright © 2010 Stephen P. Glasser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Context. The fenofibrate effect on the subclass size distribution of lipoproteins before and after a high-fat challenge is not well studied. Objective. To characterize the baseline and post-prandial response (PPL) to a high-fat challenge following fenofibrate therapy, on changes in LDL, HDL, and VLDL particle subclasses, number, and size in 271 hypertriglyceridemic participants. Methods. Participants from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study who conducted PPL studies both before and after three weeks of fenofibrate (160 mg/d) treatment were analyzed. Particle size distributions were determined using nuclear magnetic resonance imaging, and lipid determinations were measured at fasting (0 hr), 3.5 hours, and 6 hours after ingestion of a standardized high-fat meal. Analyses were stratified by gender. Changes in particle subclass distributions were assessed using repeated measures analysis of variance adjusted for pedigree. Results. Before PPL, fenofibrate in men (adjusted for age, field center, smoking status, diabetes, and weight circumference) lowered fasting and postprandial VLDL primarily due to reductions in postprandial levels of large and medium VLDL particles (9 SE +/0.7 to 4 +/0.4 and 78 =/4 to 36 =/3 nmol/L both P<.0001, resp.). Fenofibrate also reduced fasting and postprandial total LDL particles, primarily a result of reduced small LDL particles (1497 =/37 to 1088 =/36 nmol/L, P<.0001). Directional changes were similar in men and women but the magnitude of change was different for some parameters. Conclusion. Fenofibrate treatment resulted in a lower triglyceride excursion following a high-fat meal. This investigation provides new knowledge of the magnitude and time course of fenofibrate induced attenuation of Lipoprotein subclass size distribution following a postprandial lipid challenge.