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Science and Technology of Nuclear Installations
Volume 2013, Article ID 379283, 7 pages
Research Article

Influence of the Generator in-Growth Time on the Final Radiochemical Purity and Stability of Radiopharmaceuticals

1Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Sezione di Diagnostica per Immagini, Università di Ferrara and INFN, Sezione di Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy
2Dipartimento di Fisica e Scienze della Terra, Università di Ferrara and INFN, Sezione di Ferrara, Via Saragat 1, 44122 Ferrara, Italy
3INFN, Laboratori Nazionali di Legnaro (LNL), Via dell’Università 2, 35020 Legnaro, Italy

Received 31 May 2013; Accepted 13 August 2013

Academic Editor: Mushtaq Ahmad

Copyright © 2013 L. Uccelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


At Legnaro laboratories of the Italian National Institute for Nuclear Physics (INFN), a feasibility study has started since 2011 related to accelerated-based direct production of by the 100Mo(p,2n) reaction. Both theoretical investigations and some recent preliminary irradiation tests on 100Mo-enriched samples have pointed out that both the / ratio and the specific activity will be basically different in the final accelerator-produced Tc with respect to generator-produced one, which might affect the radiopharmaceutical procedures. The aim of this work was to evaluate the possible impact of different / isomeric ratios on the preparation of different Tc-labeled pharmaceutical kits. A set of measurements with , eluted from a standard 99Mo/ generator, was performed, and results on both radiochemical purity and stability studies (following the standard quality control procedures) are reported for a set of widely used pharmaceuticals (i.e., -Sestamibi, -ECD, -MAG3, -DTPA, -MDP, -HMDP, -nanocolloids, and -DMSA). These pharmaceuticals have been all reconstituted with either the first [ O4] eluate obtained from a 99Mo/ generator (coming from two different companies) or eluates after 24, 36, 48, and 72 hours from last elution. Results show that the radiochemical purity and stability of these radiopharmaceuticals were not affected up to the value of 11.84 for the / ratio.