Influence of the Generator in-Growth Time on the Final Radiochemical Purity and Stability of ^99mTc Radiopharmaceuticals

Table 4

RCP of radiopharmaceuticals at 𝑡=0, prepared with generator Elumatic III (IBA) eluates at time superior to 24 h from the last elution.

Commercial name	Radiopharmaceutical	RCP36	RCP48	RCP72	RCP requirements
Neurolite	^99mTc-ECD	98.77±0.89	99.21±0.71	98.68±0.95	≥90%
Cardiolite	^99mTc-Sestamibi	97.88±0.78	98.83±0.92	99.13±0.63	≥94%
Stamicis	^99mTc-Sestamibi	98.78±0.23	98.90±0.20	98.00±0.19	≥94%
Technemibi	^99mTc-Sestamibi	98.45±0.09	98.17±0.23	98.11±0.06	≥94%
TechneScan	^99mTc-MAG3	99.79±0.64	98.10±0.44	99.44±0.14	≥95%
Pentacis	^99mTc-DTPA	99.14±0.12	98.88±0.15	98.12±1.03	≥95%
Medronato II	^99mTc-MDP	99.11±0.33	99.44±0.15	99.11±0.43	≥95%
Osteocis	^99mTc-HMDP	99.01±0.24	98.44±0.16	99.63±0.64	≥95%
Nanocoll (PRC = 40 min)	^99mTc-nanocolloids	98.99±0.03	99.18±0.49	98.11±0.11	≥95%
Renocis	^99mTc-DMSA	99.35±0.22	98.67±0.17	99.03±0.29	≥95%

RCP_36,48,72 indicate the radiochemical purity carried out with eluates obtained 36, 48 and 72 hours after the previous elution.