In the field of structural health monitoring or machine condition monitoring, most vibration based methods reported in the literature require to measure responses at several locations on the structure. In machine condition monitoring, the number of available vibration sensors is often small and it is not unusual that only one single sensor is used to monitor a machine. The aim of this paper is to propose an extension of fault detection techniques that may be used when a reduced set of sensors or even one single sensor is available. Fault detection techniques considered here are based on output-only methods coming from the Blind Source Separation (BSS) family, namely Principal Component Analysis (PCA) and Second Order Blind Identification (SOBI). The advantages of PCA or SOBI rely on their rapidity of use and their reliability. Based on these methods, subspace identification may be performed by using the concept of block Hankel matrices which make possible the use of only one single measurement signal. Thus, the problem of fault detection in mechanical systems can be solved by using subspaces built from active principal components or modal vectors. It consists in comparing subspace features between the reference (undamaged) state and a current state. The angular coherence between subspaces is a good indicator of a dynamic change in the system due to the occurrence of faults or damages. The robustness of the methods is illustrated on industrial examples.