Scholarly Research Exchange

Scholarly Research Exchange / 2009 / Article

Case Report | Open Access

Volume 2009 |Article ID 176837 | 4 pages | https://doi.org/10.3814/2009/176837

Syringocystadenocarcinoma Papilliferum In Situ: Case Report with Immunohistochemical Observations

Received11 Feb 2009
Revised17 Mar 2009
Accepted23 Mar 2009
Published05 Apr 2009

Abstract

A 23-year-old man was operated for a skin tumor in the right axilla. Histological examination revealed findings consistent with a syringocystadenoma papilliferum. However, most of the papillary structures showed a disorganized proliferation of atypical cells without invasive growth, that is, a syringocystadenocarcinoma papilliferum in situ. Immunohistochemistry disclosed a different staining profile between the basal cells of the papillary structures and those of the columnar and atypical cells which reacted similarly. However, the atypical cells showed a stronger and more extensive expression of S-100 protein and CD56 than the columnar epithelium and a few of them also reacted with CEA. Ki-67 staining highlighted the increased proliferative activity of the atypical cells. The best antibody for depicting the basal cells was p63. In the present case immunohistochemistry was of little help to support the diagnosis of malignant transformation since the differences between the atypical and regular columnar cells were small and of a quantitative character only.

References

  1. J. J. Mammino and D. A. Vidmar, “Syringocystadenoma papilliferum,” International Journal of Dermatology, vol. 30, no. 11, pp. 763–766, 1991. View at: Publisher Site | Google Scholar
  2. E. Hedinger, “Zur Frage des Plasmocytoms (Granulationsplasmocytom in Kombination mit einem krebsig umgewandelten Schweissdrüsenadenom des behaarten Kopfes),” Frankfurter Zeitschrift für Pathologie, vol. 7, pp. 343–350, 1911. View at: Google Scholar
  3. F. Nödl, “Beitrag zum Naevus syringo-cystadenomatosus papilliferus,” Archiv für Dermatologie und Syphilis, vol. 178, no. 6, pp. 697–713, 1939. View at: Publisher Site | Google Scholar
  4. T. Maier, “Autoptisch gesichertes metastasierendes Schweissdrüsenkarzinom auf dem Boden eines Naevus syringoadenomatosus papilliferus,” Zentralblatt für Allgemeine Pathologie, vol. 85, pp. 377–380, 1949. View at: Google Scholar
  5. R. V. P. Dissanayake and R. Salm, “Sweat-gland carcinomas: prognosis related to histological type,” Histopathology, vol. 4, no. 4, pp. 445–466, 1980. View at: Publisher Site | Google Scholar
  6. M. A. Seco Navedo, M. Fresno Forcelledo, A. Orduña Domingo, P. Junco Petrement, and T. Soler Sanchez, “Syringocystadenome papillifere a evolution maligne. Presentation d'un cas,” Annales de Dermatologie et de Venereologie, vol. 109, no. 8, pp. 685–689, 1982. View at: Google Scholar
  7. D. J. Santa Cruz, “Sweat gland carcinomas: a comprehensive review,” Seminars in Diagnostic Pathology, vol. 4, no. 1, pp. 38–74, 1987. View at: Google Scholar
  8. S. Ansai, S. Koseki, H. Hashimoto, Y. Hozumi, and S. Kondo, “A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus,” Journal of Cutaneous Pathology, vol. 21, no. 6, pp. 557–563, 1994. View at: Google Scholar
  9. R. Bondi and C. Urso, “Syringocystadenocarcinoma papilliferum,” Histopathology, vol. 28, no. 5, pp. 475–477, 1996. View at: Publisher Site | Google Scholar
  10. H. Hügel and L. Requena, “Ductal carcinoma arising from a syringocystadenoma papilliferum in a nevus sebaceus of Jadassohn,” The American Journal of Dermatopathology, vol. 25, no. 6, pp. 490–493, 2003. View at: Publisher Site | Google Scholar
  11. A. Ishida-Yamamoto, K. Sato, T. Wada, H. Takahashi, and H. Iizuka, “Syringocystadenocarcinoma papilliferum: case report and immunohistochemical comparison with its benign counterpart,” Journal of the American Academy of Dermatology, vol. 45, no. 5, pp. 755–759, 2001. View at: Publisher Site | Google Scholar
  12. Y. Arai, H. Kusakabe, and K. Kiyokane, “A case of syringocystadenocarcinoma papilliferum in situ occurring partially in syringocystadenoma papilliferum,” Journal of Dermatology, vol. 30, no. 2, pp. 146–150, 2003. View at: Google Scholar
  13. D. V. Kazakov, E. Calonje, B. Zelger et al., “Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases,” The American Journal of Dermatopathology, vol. 29, no. 3, pp. 242–248, 2007. View at: Publisher Site | Google Scholar
  14. M. Numata, S. Hosoe, N. Itoh, Y. Munakata, S. Hayashi, and Y. Maruyama, “Syringadenocarcinoma papilliferum,” Journal of Cutaneous Pathology, vol. 12, no. 1, pp. 3–7, 1985. View at: Publisher Site | Google Scholar
  15. N. S. Penneys, M. Nadji, and A. Morales, “Carcinoembryonic antigen in benign sweat gland tumors,” Archives of Dermatology, vol. 118, no. 4, pp. 225–227, 1982. View at: Publisher Site | Google Scholar
  16. A. Maiorana, E. Nigrisoli, and M. Papotti, “Immunohistochemical markers of sweat gland tumors,” Journal of Cutaneous Pathology, vol. 13, no. 3, pp. 187–196, 1986. View at: Publisher Site | Google Scholar

Copyright © 2009 Christian F. Lindboe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

116 Views | 0 Downloads | 0 Citations
 PDF  Download Citation  Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.