Scholarly Research Exchange

Scholarly Research Exchange / 2009 / Article

Research Article | Open Access

Volume 2009 |Article ID 478468 | 4 pages | https://doi.org/10.3814/2009/478468

Histologic Effects of Bilateral Adrenalectomy under the Light Microscopy on Rat Mandibular Condyle

Received25 Jul 2008
Accepted13 Apr 2009
Published28 May 2009

Abstract

The aim of this study was to compare the histologic findings from the condyles of rats with the general system findings. 30 Sprague-Dawley adult rats were used. The rats were sacrified and their condyles and femurs were examined histologically. The rats’ weight were observed weekly, their femoral height and weight, femoral mineral elements, and their daily food and water consumes were recorded. The results were analysed statistically by using SPSS (10.0). During the histologic examination of femur, the osteogenesis and calcification of the femur layers of the male/female rats in the experimental group were found to be lower than those of the ones in the control group. In addition to that, during the histological examination of condyle the level of thickness of condyle layers, the number of cellular elements, the osteogenesis and calcification seemed to be decreased for the male/female rats in the experimental group than for those in the control group. The decrease was found to be more significant for the female rats than the male rats in experimental group and it is thought that this is related to the gonad hormones. These findings emphasize that a reduction of sex hormone levels, induced by adrenalectomy, significantly influences condylar histogenesis.

References

  1. M. Cotterrell, R. Balaazs, and A. L. Johnson, “Effects of corticosteroids on the biochemical maturation of rat brain: postnatal cell formation,” Journal of Neurochemistry, vol. 19, no. 9, pp. 2151–2167, 1972. View at: Publisher Site | Google Scholar
  2. A. Montoli, G. Colussi, and L. Minetti, “Hypercalcaemia in Addison's disease: calciotropic hormone profile and bone histology,” Journal of Internal Medicine, vol. 232, no. 6, pp. 535–540, 1992. View at: Google Scholar
  3. S. Ten, M. New, and N. Maclaren, “Clinical review 130: Addison's disease 2001,” The Journal of Clinical Endocrinology & Metabolism, vol. 86, no. 7, pp. 2909–2922, 2001. View at: Publisher Site | Google Scholar
  4. N. Demir and R. Demir, “Effects of maternal bilateral adrenalectomy on fetal rat cerebral cortex,” International Journal of Neuroscience, vol. 111, no. 1-2, pp. 21–38, 2001. View at: Publisher Site | Google Scholar
  5. R. H. Williams, Textbook of Endocrinology, W. B. Saunders, Philadelphia, Pa, USA, 1968.
  6. E. Zerath, X. Holy, S. G. Roberts et al., “Spaceflight inhibits bone formation independent of corticosteroid status in growing rats,” Journal of Bone and Mineral Research, vol. 15, no. 7, pp. 1310–1320, 2000. View at: Publisher Site | Google Scholar
  7. J. Fanghanel and B. Miehe, “The influence of altered occlusion on the condylar cartilage of the mandible and on the growth of the entire skull,” Annals of Anatomy, vol. 176, no. 1, pp. 61–65, 1994. View at: Google Scholar
  8. T. Fujita, T. Kawata, C. Tokimasa, S. Kohno, M. Kaku, and K. Tanne, “Breadth of the mandibular condyle affected by disturbances of the sex hormones in ovariectomized and orchiectomized mice,” Clinical Orthodontics and Research, vol. 4, no. 3, pp. 172–176, 2001. View at: Publisher Site | Google Scholar
  9. M. Delatte, J. W. Von den Hoff, R. E. M. van Rheden, and A. M. Kuijpers-Jagtman, “Primary and secondary cartilages of the neonatal rat: the femoral head and the mandibular condyle,” European Journal of Oral Sciences, vol. 112, no. 2, pp. 156–162, 2004. View at: Publisher Site | Google Scholar
  10. H. U. Luder, “Structure and growth activities of the mandibular condyle in monkeys (Macaca fascicularis)—I. Intracondylar variations,” American Journal of Anatomy, vol. 166, no. 2, pp. 223–235, 1983. View at: Publisher Site | Google Scholar
  11. T. Kantomaa, “New aspects of the histology of the mandibular condyle in the rat,” Acta Anatomica, vol. 126, no. 4, pp. 218–222, 1986. View at: Google Scholar
  12. S. B. Milam, T. B. Aufdemorte, P. J. Sheridan, R. G. Triplett, J. E. Van Sickels, and G. R. Holt, “Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 64, no. 5, pp. 527–532, 1987. View at: Publisher Site | Google Scholar

Copyright © 2009 Sabiha Zelal Ülkü et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

97 Views | 0 Downloads | 0 Citations
 PDF  Download Citation  Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.