Genes Involved in Human Ribosome Biogenesis are Transcriptionally Upregulated in Colorectal Cancer
Microarray gene expression profiling comprising 168 colorectal adenocarcinomas and 10 normal mucosas showed that over 79% of the genes involved in human ribosome biogenesis are significantly upregulated (, ) when compared to normal mucosa. Overexpression was independent of microsatellite status. The promoters of the genes studied showed a significant enrichment for several transcription factor binding sites. There was a significant correlation between the number of binding site targets for these transcription factors and the observed gene transcript upregulation. The upregulation of rRNA processing genes points towards a coordinated process enabling the overproduction of matured ribosomal structures.
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