Genes Involved in Human Ribosome Biogenesis are Transcriptionally Upregulated in Colorectal Cancer

Mansilla, Francisco; Lamy, Philippe; Ørntoft, Torben F.; Birkenkamp-Demtröder, Karin

doi:https://doi.org/10.3814/2009/657042

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Research Article | Open Access

Volume 2009 | Article ID 657042 | https://doi.org/10.3814/2009/657042

Genes Involved in Human Ribosome Biogenesis are Transcriptionally Upregulated in Colorectal Cancer

Francisco Mansilla,¹Philippe Lamy,¹Torben F. Ørntoft,¹and Karin Birkenkamp-Demtröder¹

Received01 Jan 2009

Revised03 May 2009

Accepted20 May 2009

Published07 Jun 2009

Abstract

Microarray gene expression profiling comprising 168 colorectal adenocarcinomas and 10 normal mucosas showed that over 79% of the genes involved in human ribosome biogenesis are significantly upregulated (log2>0.5, p<10−3) when compared to normal mucosa. Overexpression was independent of microsatellite status. The promoters of the genes studied showed a significant enrichment for several transcription factor binding sites. There was a significant correlation between the number of binding site targets for these transcription factors and the observed gene transcript upregulation. The upregulation of rRNA processing genes points towards a coordinated process enabling the overproduction of matured ribosomal structures.

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Copyright

Copyright © 2009 Francisco Mansilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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