Urinary Prothrombin Fragment 1+2 in relation to Development of Non-Symptomatic and Symptomatic Venous Thromboembolic Events following Total Knee Replacement
Table 4
Results for patients with symptomatic venous thromboembolic events. Patients with symptomatic venous thromboembolic events, type of event, day of event, day of venography, and levels of prothrombin fragment 1+2 excreted in urine preoperatively and on the day of venography. Lower limit of detection 20 pmol/L, upper limit 1,200 pmol/L. CT: computerized tomography; CUS: compression ultrasound; DVT: deep vein thrombosis; NS: no urine sample; PE: pulmonary embolism; uF1+2: prothrombin fragment 1+2 excreted in urine.
Sex, M/F
Age, years
uF1+2 preoperatively, pmol/L
Day of venography (day of urine sampling)
uF1+2 on day of venography, pmol/L
Type of event
Day of event
Comment
F
71
NS
10
<20
PE
14
Bilateral asymptomatic distal DVT. Not treated. Fatal PE could not be excluded, but was never objectively confirmed
F
53
27
8
<20
PE
23
Planned venography normal
F
68
<20
—
NS
PE
4
PE confirmed by CT
M
62
<20
—
NS
PE
8
PE confirmed by CT
M
51
68.1
8
702.5
DVT
8
Distal DVT. Diagnosed by planned venography
F
73
21.5
6
46.5
DVT
7
Distal DVT. Symptoms appeared on the day after the planned venography
F
55
35.4
5
28.5
DVT
7
Distal DVT. Diagnosed by planned venography
F
80
<20
7
31.6
DVT
7
Distal DVT. Diagnosed by planned venography
F
60
<20
—
NS
DVT
7
Diagnosed by planned venography
F
71
58.7
6
168.2
DVT
16
Proximal DVT. Planned venography normal. CUS diagnosis on the event day
