Table of Contents
Thrombosis
Volume 2012 (2012), Article ID 156397, 6 pages
http://dx.doi.org/10.1155/2012/156397
Review Article

Experimental Validation of Methods for Prophylaxis against Deep Venous Thrombosis: A Review and Proposal

1Theoretical Medicine and Biology Group, 26 Castle Hill, Glossop, Derbyshire, UK
2Department of Pathology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
3Centre for Comparative and Clinical Anatomy, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK

Received 2 December 2011; Revised 20 January 2012; Accepted 6 February 2012

Academic Editor: Debra A. Hoppensteadt

Copyright © 2012 Paul S. Agutter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. B. Rothberg, M. Lahti, P. S. Pekow, and P. K. Lindenauer, “Venous thromboembolism prophylaxis among medical patients at us hospitals,” Journal of General Internal Medicine, vol. 25, no. 6, pp. 489–494, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Sliwka and M. C. Fang, “Venous thromboembolism prophylaxis in the United States: still room for improvement,” Journal of General Internal Medicine, vol. 25, no. 6, pp. 484–486, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Khoury, S. Welner, M. Kubin, K. Folkerts, and S. Haas, “Disease burden and unmet needs for prevention of venous thromboembolism in medically ill patients in Europe show underutilization of preventive therapies,” Thrombosis and Haemostasis, vol. 106, no. 4, pp. 600–608, 2011. View at Google Scholar
  4. A. Qaseem, R. Chou, L. L. Humphrey, M. Starkey, and P. Shekelle, “Venous thromboembolism prophylaxis in hospitalized patients: a clinical practice guideline from the American College of Physicians,” Annals of Internal Medicine, vol. 155, no. 9, pp. 625–632, 2011. View at Google Scholar
  5. E. G. Bovill and A. Van Der Vliet, “Venous valvular stasis-associated hypoxia and thrombosis: what is the link?” Annual Review of Physiology, vol. 73, pp. 527–545, 2011. View at Publisher · View at Google Scholar
  6. D. K. Cundiff, P. S. Agutter, P. C. Malone, and J. C. Pezzullo, “Diet as prophylaxis and treatment for venous thromboembolism?” Theoretical Biology and Medical Modelling, vol. 7, no. 1, article no. 31, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. P. D. Stein, F. Matta, and J. E. Dalen, “Is the campaign to prevent VTE in hospitalized patients working?” Chest, vol. 139, no. 6, pp. 1317–1321, 2011. View at Publisher · View at Google Scholar
  8. G. Piazza, T. N. Nguyen, D. Cios et al., “Anticoagulation-related adverse drug events,” The American Journal of Medicine, vol. 124, no. 12, pp. 1136–1142, 2011. View at Google Scholar
  9. P. B. Samuels and D. R. Webster, “The role of venous endothelium in the inception of thrombosis,” Annals of Surgery, vol. 136, no. 3, pp. 422–438, 1952. View at Google Scholar
  10. P. C. Malone and P. S. Agutter, “The aetiology of deep venous thrombosis,” QJM, vol. 99, no. 9, pp. 581–593, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. P. C. Malone and P. S. Agutter, The Aetiology of Deep Venous Thrombosis, Springer, Dordrecht, The Netherlands, 2008.
  12. J. D. Hamer and P. C. Malone, “Experimental deep venous thrombogenesis by a non-invasive method,” Annals of the Royal College of Surgeons of England, vol. 66, no. 6, pp. 416–419, 1984. View at Google Scholar · View at Scopus
  13. F. Lurie, R. L. Kistner, and B. Eklof, “The mechanism of venous valve closure in normal physiologic conditions,” Journal of Vascular Surgery, vol. 35, no. 4, pp. 713–717, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Lurie, R. L. Kistner, B. Eklof, and D. Kessler, “Mechanism of venous valve closure and role of the valve in circulation: a new concept,” Journal of Vascular Surgery, vol. 38, no. 5, pp. 955–961, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Karino and M. Motomiya, “Flow through a venous valve and its implication for thrombus formation,” Thrombosis Research, vol. 36, no. 3, pp. 245–257, 1984. View at Google Scholar · View at Scopus
  16. T. Karino, “Microscopic structure of disturbed flows in the arterial and venous systems, and its implication in the localization of vascular diseases,” International Angiology, vol. 5, no. 4, pp. 297–313, 1986. View at Google Scholar · View at Scopus
  17. T. Karino and H. L. Goldsmith, “Rheological factors in thrombosis and haemostasis,” in Haemostasis and Thrombosis, A. L. Bloom and D. P. Thomas, Eds., Churchill Livingstone, Edinburgh, UK, 1987. View at Google Scholar
  18. J. D. Hamer, P. C. Malone, and I. A. Silver, “The P(O2) in venous valve pockets: its possible bearing on thrombogenesis,” British Journal of Surgery, vol. 68, no. 3, pp. 166–170, 1981. View at Google Scholar · View at Scopus
  19. R. M. Jackson, H. Soo Ann, and S. Oparil, “Hypoxia-induced oxygen tolerance: maintenance of endothelial metabolic function,” Experimental Lung Research, vol. 14, pp. 887–896, 1988. View at Google Scholar · View at Scopus
  20. K. J. Franklin, A Monograph on Veins, chapter 5, Charles Thomas, Springfield, Ill, USA, 1937.
  21. O. Saphir and M. Lev, “Venous valvulitis,” Archives of Pathology, vol. 53, no. 5, pp. 456–469, 1952. View at Google Scholar
  22. O. Saphir and M. Lev, “The venous valve in the aged,” American Heart Journal, vol. 44, no. 6, pp. 843–850, 1952. View at Google Scholar · View at Scopus
  23. S. Sevitt, “Organization of valve pocket thrombi and the anomalies of double thrombi and valve cusp involvement,” British Journal of Surgery, vol. 61, no. 8, pp. 641–649, 1974. View at Google Scholar · View at Scopus
  24. D. J. Pinsky, S. F. Yan, C. Lawson et al., “Hypoxia and modification of the endothelium: implications for regulation of vascular homeostatic properties,” Seminars in Cell and Developmental Biology, vol. 6, no. 5, pp. 283–294, 1995. View at Google Scholar · View at Scopus
  25. S. F. Yan, N. Mackman, W. Kisiel, D. M. Stern, and D. J. Pinsky, “Hypoxia/hypoxemia-induced activation of the procoagulant pathways and the pathogenesis of ischemia-associated thrombosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 19, no. 9, pp. 2029–2035, 1999. View at Google Scholar · View at Scopus
  26. S. F. Yan, J. Lu, Y. S. Zou et al., “Hypoxia-associated induction of early growth response-1 gene expression,” Journal of Biological Chemistry, vol. 274, no. 21, pp. 15030–15040, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Karimova and D. J. Pinsky, “The endothelial response to oxygen deprivation: biology and clinical implications,” Intensive Care Medicine, vol. 27, no. 1, pp. 19–31, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. R. L. K. Virchow, “Thrombosis und Embolie,” in Klassiker der Medizin, K. Sudhoff, Ed., pp. 1846–1856, J. A. Barth, Leipzig, Germany, 1910. View at Google Scholar
  29. R. L. K. Virchow, Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre, A. Hirschwald, Berlin, Germany, 1858.
  30. R. L. K. Virchow, Gessamelte Abhandlungen zur wissenschaftlichen Medizin von Rudolf Virchow, Meidinger, Frankfurt am Main, Germany, 1862.
  31. F. W. Zahn, “Untersuchungen über Thrombose,” Zentralblatt für den medizinische Wissenschaft, vol. 10, pp. 129–153, 1876. View at Google Scholar
  32. W. H. Welch, “The structure of white thrombi,” Transactions of the Pathological Society of Philadelphia, vol. 13, pp. 281–300, 1887. View at Google Scholar
  33. L. Aschoff, Lectures in General Pathology, Hoeber, New York, NY, USA, 1924.
  34. J. McLachlin and J. C. Paterson, “Some basic observations on venous thrombosis and pulmonary embolism,” Surgery, Gynecology & Obstetrics, vol. 93, no. 1, pp. 1–8, 1951. View at Google Scholar · View at Scopus
  35. J. C. Paterson and J. McLachlin, “Precipitating factors in venous thrombosis,” Surgery, Gynecology and Obstetrics, vol. 98, no. 1, pp. 96–102, 1954. View at Google Scholar
  36. P. D. Stein and H. Evans, “An autopsy study of leg vein thrombosis,” Circulation, vol. 35, no. 4, pp. 671–681, 1967. View at Google Scholar · View at Scopus
  37. W. H. Geerts, D. Bergqvist, G. F. Pineo et al., “Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition),” Chest, vol. 133, no. 6, pp. 381S–453S, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. F. R. Rosendaal, “Venous thrombosis: a multicausal disease,” Lancet, vol. 353, no. 9159, pp. 1167–1173, 1999. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Lippi and M. Franchini, “Pathogenesis of venous thromboembolism: when the cup runneth over,” Seminars in Thrombosis and Hemostasis, vol. 34, no. 8, pp. 747–761, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. J. J. Mazza, “Hypercoagulability and venous thromboembolism: a review,” Wisconsin Medical Journal, vol. 103, no. 2, pp. 41–49, 2004. View at Google Scholar · View at Scopus
  41. F. R. Rosendaal, “Venous thrombosis: the role of genes, environment, and behaviour,” American Society of Hematology, Education Program, pp. 1–12, 2005. View at Google Scholar
  42. H. I. Hassouna, “Thrombophilia and hypercoagulability,” Medical Principles and Practice, vol. 18, no. 6, pp. 429–440, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. J. A. M. Anderson and J. I. Weitz, “Hypercoagulable states,” Clinics in Chest Medicine, vol. 31, no. 4, pp. 659–673, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. R. P. Pitto, H. Hamer, W. Heiss-Dunlop, and J. Kuehle, “Mechanical prophylaxis of deep-vein thrombosis after total hip replacement. A randomised clinical trial,” Journal of Bone and Joint Surgery B, vol. 86, no. 5, pp. 639–642, 2004. View at Publisher · View at Google Scholar
  45. C. W. Colwell Jr., “DVT prevention: mobile compression device vs low-molecular-weight heparin,” Orthopedics, vol. 33, no. 5, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. R. Yokote, M. Matsubara, N. Hirasawa, S. Hagio, K. Ishii, and C. Takata, “Is routine chemical thromboprophylaxis after total hip replacement really necessary in a Japanese population?” Journal of Bone and Joint Surgery B, vol. 93, no. 2, pp. 251–256, 2011. View at Publisher · View at Google Scholar