Table of Contents
Thrombosis
Volume 2012 (2012), Article ID 676237, 4 pages
http://dx.doi.org/10.1155/2012/676237
Research Article

Paradoxical Effect of Aspirin

1Laboratoire d’Hématologie, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
2CEBBAD, Universidad Maimónides, Buenos Aires C1405BCK, Argentina

Received 15 June 2011; Accepted 8 October 2011

Academic Editor: Jawad Fareed

Copyright © 2012 Christian Doutremepuich et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) collaborative group,” The Lancet, vol. 2, pp. 349–360, 1988.
  2. UK-TIA Study Group, “The United Kingdom transient ischemic attack (UK-TIA) aspirin trial: final results,” Journal of Neurology Neurosurgery and Psychiatry, vol. 54, no. 12, pp. 1261–1266, 1991. View at Google Scholar
  3. S. Jull-Mőller, N. Edvardsson, B. Jahnmatz, A. Rosen, S. Sorensen, and R. Omblus, “Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris. The Swedish angina pectoris aspirin trial (SAPAT) group,” The Lancet, vol. 340, no. 8833, pp. 1421–1425, 1992. View at Publisher · View at Google Scholar
  4. “Final report on the aspirin component of the ongoing Physicians' health study. Steering committee of the physicians' health study research group,” The New England Journal of Medicine, vol. 321, pp. 129–135, 1989.
  5. “Stroke prevention in atrial fibrillation study. Final results,” Circulation, vol. 84, no. 2, pp. 527–539, 1991. View at Scopus
  6. “Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients,” British Medical Journal, vol. 324, no. 7329, pp. 71–86, 2002. View at Scopus
  7. G. Boysen, “Bleeding complications in secondary stroke prevention by antiplatelet therapy: a benefit-risk analysis,” Journal of Internal Medicine, vol. 246, no. 3, pp. 239–245, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. J. R. Vane, “Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs,” Nature New Biology, vol. 231, no. 25, pp. 232–235, 1971. View at Google Scholar · View at Scopus
  9. O. Aguejouf, F. Eizayaga, V. Desplat, P. Belon, and C. Doutremepuich, “Prothrombotic and hemorrhagic effects of aspirin,” Clinical and Applied Thrombosis/Hemostasis, vol. 15, no. 5, pp. 523–528, 2009. View at Publisher · View at Google Scholar
  10. I. Sibon and J. M. Orgogozo, “Antiplatelet drug discontinuation is a risk factor for ischemic stroke,” Neurology, vol. 62, no. 7, pp. 1187–1189, 2004. View at Google Scholar · View at Scopus
  11. J. L. Masferrer, B. S. Zweifel, P. T. Manning et al., “Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 8, pp. 3228–3232, 1994. View at Google Scholar · View at Scopus
  12. T. Wolff, T. Miller, and S. Ko, “Aspirin for the primary prevention of cardiovascular events: an update of the evidence for the U.S. preventive services task force,” Annals of Internal Medicine, vol. 150, no. 6, pp. 405–410, 2009. View at Google Scholar · View at Scopus
  13. N. J. Skill, N. G. Theodorakis, Y. N. Wang, J. M. Wu, E. M. Redmond, and J. V. Sitzmann, “Role of cyclooxygenase isoforms in prostacyclin biosynthesis and murine prehepatic portal hypertension,” American Journal of Physiology, vol. 295, no. 5, pp. G953–G964, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Taubert, R. Berkels, N. Grosser, H. Schröder, D. Gründemann, and E. Schömig, “Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action,” British Journal of Pharmacology, vol. 143, no. 1, pp. 159–165, 2004. View at Publisher · View at Google Scholar · View at Scopus