Table of Contents
Thrombosis
Volume 2012, Article ID 694851, 9 pages
http://dx.doi.org/10.1155/2012/694851
Review Article

Evaluating the Role of Compression Stockings in Preventing Post thrombotic Syndrome: A Review of the Literature

Department of Pharmacy Practice, College of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, MA 01608, USA

Received 14 June 2011; Accepted 29 November 2011

Academic Editor: Tomohiro Ogawa

Copyright © 2012 Abir O. Kanaan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. R. Kahn and J. S. Ginsberg, “Relationship between deep venous thrombosis and the postthrombotic syndrome,” Archives of Internal Medicine, vol. 164, no. 1, pp. 17–26, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. P. Prandoni, A. W. A. Lensing, A. Cogo et al., “The long-term clinical course of acute deep venous thrombosis,” Annals of Internal Medicine, vol. 125, no. 1, pp. 1–7, 1996. View at Google Scholar · View at Scopus
  3. S. Schulman, P. Lindmarker, M. Holmström et al., “Post-thrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 months,” Journal of Thrombosis and Haemostasis, vol. 4, no. 4, pp. 734–742, 2006. View at Publisher · View at Google Scholar · View at PubMed
  4. H. Shbaklo and S. R. Kahna, “Long-term prognosis after deep venous thrombosis,” Current Opinion in Hematology, vol. 15, no. 5, pp. 494–498, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. S. R. Kahn, I. Shrier, J. A. Julian et al., “Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis,” Annals of Internal Medicine, vol. 149, no. 10, pp. 698–707, 2008. View at Google Scholar · View at Scopus
  6. L. W. Tick, M. H. H. Kramer, F. R. Rosendaal, W. R. Faber, and C. J. M. Doggen, “Risk factors for post-thrombotic syndrome in patients with a first deep venous thrombosis,” Journal of Thrombosis and Haemostasis, vol. 6, no. 12, pp. 2075–2081, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. P. Prandoni, A. W. A. Lensing, M. H. Prins et al., “Below-knee elastic compression stockings to prevent the post-thrombotic syndrome. A randomized, controlled trial,” Annals of Internal Medicine, vol. 141, no. 4, pp. 249–256, 2004. View at Google Scholar · View at Scopus
  8. S. R. Kahn, H. Partsch, S. Vedantham, P. Prandoni, and C. Kearon, “Definition of post-thrombotic syndrome of the leg for use in clinical investigations: a recommendation for standardization,” Journal of Thrombosis and Haemostasis, vol. 7, no. 5, pp. 879–883, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. D. N. Mohr, M. D. Silverstein, J. A. Heit, T. M. Petterson, W. Michael O'Fallon, and L. Joseph Melton, “The venous stasis syndrome after deep venous thrombosis or pulmonary embolism: a population-based study,” Mayo Clinic Proceedings, vol. 75, no. 12, pp. 1249–1256, 2000. View at Google Scholar · View at Scopus
  10. S. R. Kahn, “The post-thrombotic syndrome: progress and pitfalls,” British Journal of Haematology, vol. 134, no. 4, pp. 357–365, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. E. J. Immelman and P. C. Jeffery, “The postphlebitic syndrome. Pathophysiology, prevention and management,” Clinics in Chest Medicine, vol. 5, no. 3, pp. 537–550, 1984. View at Google Scholar · View at Scopus
  12. S. R. Kahn, S. Solymoss, D. L. Lamping, and L. Abenhaim, “Long-term outcomes after deep vein thrombosis: postphlebitic syndrome and quality of life,” Journal of General Internal Medicine, vol. 15, no. 6, pp. 425–429, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. S. R. Kahn, A. Hirsch, and I. Shrier, “Effect of postthrombotic syndrome on health-related quality of life after deep venous thrombosis,” Archives of Internal Medicine, vol. 162, no. 10, pp. 1144–1148, 2002. View at Google Scholar · View at Scopus
  14. S. R. Kahn and J. S. Ginsberg, “The post-thrombotic syndrome: current knowledge, controversies, and directions for future research,” Blood Reviews, vol. 16, no. 3, pp. 155–165, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. S. R. Kahn, H. Shbaklo, D. L. Lamping et al., “Determinants of health-related quality of life during the 2 years following deep vein thrombosis,” Journal of Thrombosis and Haemostasis, vol. 6, no. 7, pp. 1105–1112, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. A. A. Ashrani, M. D. Silverstein, T. W. Rooke et al., “Impact of venous thromboembolism, venous stasis syndrome, venous outflow obstruction and venous valvular incompetence on quality of life and activities of daily living: a nested case-control study,” Vascular Medicine, vol. 15, no. 5, pp. 387–397, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. S. R. Kahn, D. L. Lamping, T. Ducruet et al., “VEINES-QOL/Sym questionnaire was a reliable and valid disease-specific quality of life measure for deep venous thrombosis,” Journal of Clinical Epidemiology, vol. 59, no. 10, pp. 1049–1056, 2006. View at Google Scholar
  18. T. Phillips, B. Stanton, A. Provan, and R. Lew, “A study of the impact of leg ulcers on quality of life: financial, social, and psychologic implications,” Journal of the American Academy of Dermatology, vol. 31, no. 1, pp. 49–53, 1994. View at Google Scholar · View at Scopus
  19. D. Bergqvist, S. Jendteg, L. Johansen, U. Persson, and K. Ödegaard, “Cost of long-term complications of deep venous thrombosis of the lower extremities: an analysis of a defined patient population in Sweden,” Annals of Internal Medicine, vol. 126, no. 6, pp. 454–457, 1997. View at Google Scholar · View at Scopus
  20. J. A. Caprini, M. F. Botteman, J. M. Stephens et al., “Economic burden of long-term complications of deep vein thrombosis after total hip replacement surgery in the United States,” Value in Health, vol. 6, no. 1, pp. 59–74, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. D. A. MacDougall, A. L. Feliu, S. J. Boccuzzi, and J. Lin, “Economic burden of deep-vein thrombosis, pulmonary embolism, and post-thrombotic syndrome,” American Journal of Health-System Pharmacy, vol. 63, no. 20, pp. S5–S15, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. E. Ramacciotti, M. Gomes, E. T. de Aguiar et al., “A cost analysis of the treatment of patients with post-thrombotic syndrome in Brazil,” Thrombosis Research, vol. 118, no. 6, pp. 699–704, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. E. M. Roumen-Klappe, M. den Heijer, S. H. M. Van Uum, J. Van Der Ven-Jongekrijg, F. D. Van Der Graaf, and H. Wollersheim, “Inflammatory response in the acute phase of deep vein thrombosis,” Journal of Vascular Surgery, vol. 35, no. 4, pp. 701–706, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. E. A. Fox and S. R. Kahn, “The relationship between inflammation and venous thrombosis. A systematic review of clinical studies,” Thrombosis and Haemostasis, vol. 94, no. 2, pp. 362–365, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. M. T. Caps, R. A. Manzo, R. O. Bergelin, M. H. Meissner, and D. E. Strandness Jr., “Venous valvular reflux in veins not involved at the time of acute deep vein thrombosis,” Journal of Vascular Surgery, vol. 22, no. 5, pp. 524–531, 1995. View at Publisher · View at Google Scholar
  26. N. F. G. Hopkins and J. H. N. Wolfe, “Deep venous insufficiency and occlusion,” British Medical Journal, vol. 304, no. 6819, pp. 107–110, 1992. View at Google Scholar · View at Scopus
  27. F. Piovella, L. Crippa, M. Barone et al., “Normalization rates of compression ultrasonography in patients with a first episode of deep vein thrombosis of the lower limbs: association with DVT recurrence and new thrombosis,” Haematologica, vol. 87, no. 5, pp. 515–522, 2002. View at Google Scholar · View at Scopus
  28. P. Prandoni, A. W. A. Lensing, M. H. Prins et al., “Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism,” Annals of Internal Medicine, vol. 137, no. 12, pp. 955–960, 2002. View at Google Scholar · View at Scopus
  29. P. Prandoni, M. Frulla, D. Sartor, A. Concolato, and A. Girolami, “Venous abnormalities and the post-thrombotic syndrome,” Journal of Thrombosis and Haemostasis, vol. 3, no. 2, pp. 401–402, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. P. Prandoni, M. H. Prins, A. W. A. Lensing et al., “Annals of internal medicine, residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis, A randomized trial,” Annals of Internal Medicine, vol. 150, no. 9, pp. 577–585, 2009. View at Google Scholar · View at Scopus
  31. E. M. Roumen-Klappe, M. den Heijer, M. C. H. Janssen, C. van der Vleuten, T. Thien, and H. Wollersheim, “The post-thrombotic syndrome: incidence and prognostic value of non-invasive venous examinations in a six-year follow-up study,” Thrombosis and Haemostasis, vol. 94, no. 4, pp. 825–830, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. R. B. McLafferty, “Evidence of prevention and treatment of postthrombotic syndrome,” Journal of Vascular Surgery, vol. 52, no. 5, pp. 69S–73S, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Prandoni and S. R. Kahn, “Post-thrombotic syndrome: prevalence, prognostication and need for progress,” British Journal of Haematology, vol. 145, no. 3, pp. 286–295, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. J. S. Ginsberg, M. Gent, F. Turkstra et al., “Postthrombotic syndrome after hip or knee arthroplasty: a cross- sectional study,” Archives of Internal Medicine, vol. 160, no. 5, pp. 669–672, 2000. View at Google Scholar
  35. S. Villalta, P. Bagatella, A. Piccioli, A. W. Lensing, and M. H. Prins, “Assessment of validity and reproducibility of a clinical scale for the post-thrombotic syndrome,” Haemostasis, vol. 24, supplement 1, 1994. View at Google Scholar
  36. R. B. Rutherford, F. T. Padberg, A. J. Comerota, R. L. Kistner, M. H. Meissner, and G. L. Moneta, “Venous severity scoring: an adjunct to venous outcome assessment,” Journal of Vascular Surgery, vol. 31, no. 6, pp. 1307–1312, 2000. View at Publisher · View at Google Scholar
  37. J. M. Porter and G. L. Moneta, “Reporting standards in venous disease: an update,” Journal of Vascular Surgery, vol. 21, no. 4, pp. 635–645, 1995. View at Publisher · View at Google Scholar
  38. D. P. M. Brandjes, H. R. Büller, H. Heijboer et al., “Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis,” The Lancet, vol. 349, no. 9054, pp. 759–762, 1997. View at Publisher · View at Google Scholar
  39. H. Partsch and W. Blättler, “Compression and walking versus bed rest in the treatment of proximal deep venous thrombosis with low molecular weight heparin,” Journal of Vascular Surgery, vol. 32, no. 5, pp. 861–869, 2000. View at Publisher · View at Google Scholar · View at PubMed
  40. J. S. Ginsberg, J. Hirsh, J. Julian et al., “Prevention and treatment of postphlebitic syndrome: results of a 3-part study,” Archives of Internal Medicine, vol. 161, no. 17, pp. 2105–2109, 2001. View at Publisher · View at Google Scholar
  41. H. Partsch, M. Kaulich, and W. Mayer, “Immediate mobilisation in acute vein thrombosis reduces post-thrombotic syndrome,” International Angiology, vol. 23, no. 3, pp. 206–212, 2004. View at Google Scholar
  42. M. Aschwanden, C. Jeanneret, M. T. Koller, C. Thalhammer, H. C. Bucher, and K. A. Jaeger, “Effect of prolonged treatment with compression stockings to prevent post-thrombotic sequelae: a randomized controlled trial,” Journal of Vascular Surgery, vol. 47, no. 5, pp. 1015–1021, 2008. View at Publisher · View at Google Scholar · View at PubMed
  43. S. Villalta, P. Prandoni, A. Cogo et al., “The utility of non-invasive tests for detection of previous proximal-vein thrombosis,” Thrombosis and Haemostasis, vol. 73, no. 4, pp. 592–596, 1995. View at Google Scholar
  44. K. Rabinov and S. Paulin, “Roentgen diagnosis of venous thrombosis in the leg,” Archives of Surgery, vol. 104, no. 2, pp. 134–144, 1972. View at Google Scholar
  45. T. Vrtiska and J. Glockner, “Computed tomography and magnetic resonance imaging in venous disease,” in Handbook of Venous Disorders, P. Gloviczki, Ed., Edward Arnold, London, UK, 3rd edition, 2009. View at Google Scholar
  46. S. R. Kahn, “Measurement properties of the Villalta scale to define and classify the severity of the post-thrombotic syndrome,” Journal of Thrombosis and Haemostasis, vol. 7, no. 5, pp. 884–888, 2009. View at Publisher · View at Google Scholar · View at PubMed
  47. C. J. J. van Dongen, P. Prandoni, M. Frulla, A. Marchiori, M. H. Prins, and B. A. Hutten, “Relation between quality of anticoagulant treatment and the development of the postthrombotic syndrome,” Journal of Thrombosis and Haemostasis, vol. 3, no. 5, pp. 939–942, 2005. View at Publisher · View at Google Scholar · View at PubMed
  48. M. Stain, V. Schönauer, E. Minar et al., “The post-thrombotic syndrome: risk factors and impact on the course of thrombotic disease,” Journal of Thrombosis and Haemostasis, vol. 3, no. 12, pp. 2671–2676, 2005. View at Publisher · View at Google Scholar · View at PubMed
  49. M. H. Meissner, M. T. Caps, B. K. Zierler et al., “Determinants of chronic venous disease after acute deep venous thrombosis,” Journal of Vascular Surgery, vol. 28, no. 5, pp. 826–833, 1998. View at Google Scholar
  50. M. Monreal, A. Martorell, J. M. Callejas et al., “Venographic assessment of deep vein thrombosis and risk of developing post-thrombotic syndrome: a prospective study,” Journal of Internal Medicine, vol. 233, no. 3, pp. 233–238, 1993. View at Google Scholar
  51. D. J. Lindner, J. M. Edwards, and E. S. Phinney, “Long-term hemodynamic and clinical sequelae of lower extremity deep vein thrombosis,” Journal of Vascular Surgery, vol. 4, no. 5, pp. 436–442, 1986. View at Google Scholar
  52. S. Schulman, S. Granqvist, A. Juhlin-Dannfelt, and D. Lockner, “Long-term sequelae of calf vein thrombosis treated with heparin or low-dose streptokinase,” Acta Medica Scandinavica, vol. 219, no. 4, pp. 349–357, 1986. View at Google Scholar
  53. R. B. McLafferty, G. L. Moneta, M. A. Passman et al., “Late clinical and hemodynamic sequelae of isolated calf vein thrombosis,” Journal of Vascular Surgery, vol. 27, no. 1, pp. 50–57, 1998. View at Publisher · View at Google Scholar
  54. C. Bova, V. Rossi, R. Ricchio et al., “Incidence of post-thrombotic syndrome in patients with previous pulmonary embolism. A retrospective cohort study,” Thrombosis and Haemostasis, vol. 92, no. 5, pp. 993–996, 2004. View at Publisher · View at Google Scholar
  55. P. Wille-Jørgensen, L. N. Jorgensen, and M. Crawford, “Asymptomatic postoperative deep vein thrombosis and the development of postthrombotic syndrome. A systematic review and meta-analysis,” Thrombosis and Haemostasis, vol. 93, no. 2, pp. 236–241, 2005. View at Publisher · View at Google Scholar
  56. O. S. Schindler and R. Dalziel, “Post-thrombotic syndrome after total hip or knee arthroplasty: incidence in patients with asymptomatic deep venous thrombosis,” Journal of Orthopaedic Surgery, vol. 13, no. 2, pp. 113–119, 2005. View at Google Scholar
  57. S. J. Fitzgerald, C. M. McAndrew, M. J. Kraay, and V. M. Goldberg, “Incidence of postthrombotic syndrome in patients undergoing primary total hip arthroplasty for osteoarthritis,” Clinical Orthopaedics and Related Research, vol. 469, no. 2, pp. 530–534, 2011. View at Publisher · View at Google Scholar · View at PubMed
  58. S. R. Kahn, C. Kearon, J. A. Julian et al., “Predictors of the post-thrombotic syndrome during long-term treatment of proximal deep vein thrombosis,” Journal of Thrombosis and Haemostasis, vol. 3, no. 4, pp. 718–723, 2005. View at Publisher · View at Google Scholar · View at PubMed
  59. S. R. Kahn, “How I treat postthrombotic syndrome,” Blood, vol. 114, no. 21, pp. 4624–4631, 2009. View at Publisher · View at Google Scholar · View at PubMed
  60. E. Biguzzi, E. Mozzi, A. Alatri, E. Taioli, M. Moia, and P. M. Mannucci, “The post-thrombotic syndrome in young women: retrospective evaluation of prognostic factors,” Thrombosis and Haemostasis, vol. 80, no. 4, pp. 575–577, 1998. View at Google Scholar
  61. W. Ageno, E. Piantanida, F. Dentali et al., “Body mass index is associated with the development of the post-thrombotic syndrome: results of a prospective cohort study,” Thrombosis and Haemostasis, vol. 89, no. 2, pp. 305–309, 2003. View at Google Scholar
  62. K. Bauer, “Hypercoagulable states,” Hematology, vol. 10, supplement 1, 2005. View at Google Scholar
  63. G. Palareti and B. Cosmi, “Predicting the risk of recurrence of venous thromboembolism,” Current Opinion in Hematology, vol. 11, no. 3, pp. 192–197, 2004. View at Publisher · View at Google Scholar
  64. R. K. MacKenzie, C. A. Ludlam, C. V. Ruckley, P. L. Allan, P. Burns, and A. W. Bradbury, “The prevalence of thrombophilia in patients with chronic venous leg ulceration,” Journal of Vascular Surgery, vol. 35, no. 4, pp. 718–722, 2002. View at Publisher · View at Google Scholar
  65. E. M. Roumen-Klappe, M. C. H. Janssen, J. van Rossum et al., “Inflammation in deep vein thrombosis and the development of post-thrombotic syndrome: a prospective study,” Journal of Thrombosis and Haemostasis, vol. 7, no. 4, pp. 582–587, 2009. View at Publisher · View at Google Scholar · View at PubMed
  66. H. Shbaklo, C. A. Holcroft, and S. R. Kahn, “Levels of inflammatory markers and the development of the post-thrombotic syndrome,” Thrombosis and Haemostasis, vol. 101, no. 3, pp. 505–512, 2009. View at Publisher · View at Google Scholar
  67. L. Young, P. Ockelford, D. Milne, V. Rolfe-Vyson, S. Mckelvie, and P. Harper, “Post-treatment residual thrombus increases the risk of recurrent deep vein thrombosis and mortality,” Journal of Thrombosis and Haemostasis, vol. 4, no. 9, pp. 1919–1924, 2006. View at Publisher · View at Google Scholar · View at PubMed
  68. T. Yamaki, M. Nozaki, H. Sakurai, M. Takeuchi, K. Soejima, and T. Kono, “High peak reflux velocity in the proximal deep veins is a strong predictor of advanced post-thrombotic sequelae,” Journal of Thrombosis and Haemostasis, vol. 5, no. 2, pp. 305–312, 2007. View at Publisher · View at Google Scholar · View at PubMed
  69. M. Cushman, A. R. Folsom, L. Wang et al., “Fibrin fragment D-dimer and the risk of future venous thrombosis,” Blood, vol. 101, no. 4, pp. 1243–1248, 2003. View at Publisher · View at Google Scholar · View at PubMed
  70. B. Cosmi, C. Legnani, M. Cini, G. Guazzaloca, and G. Palareti, “D-dimer levels in combination with residual venous obstruction and the risk of recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis,” Thrombosis and Haemostasis, vol. 94, no. 5, pp. 969–974, 2005. View at Publisher · View at Google Scholar · View at PubMed
  71. S. Raju and P. Neglén, “Percutaneous recanalization of total occlusions of the iliac vein,” Journal of Vascular Surgery, vol. 50, no. 2, pp. 360–368, 2009. View at Publisher · View at Google Scholar · View at PubMed
  72. S. M. Wang, Z. J. Hu, S. Q. Li, X. L. Huang, and C. S. Ye, “Effect of external valvuloplasty of the deep vein in the treatment of chronic venous insufficiency of the lower extremity,” Journal of Vascular Surgery, vol. 44, no. 6, pp. 1296–1300, 2006. View at Publisher · View at Google Scholar · View at PubMed
  73. M. K. Laiho, A. Oinonen, N. Sugano et al., “Preservation of venous valve function after catheter-directed and systemic thrombolysis for deep venous thrombosis,” European Journal of Vascular and Endovascular Surgery, vol. 28, no. 4, pp. 391–396, 2004. View at Publisher · View at Google Scholar · View at PubMed
  74. M. Elsharawy and E. Elzayat, “Early results of thrombolysis versus anticoagulation in iliofemoral venous thrombosis. A randomised clinical trial,” European Journal of Vascular and Endovascular Surgery, vol. 24, no. 3, pp. 209–214, 2002. View at Publisher · View at Google Scholar
  75. C. Kearon, S. R. Kahn, G. Agnelli, S. Goldhaber, G. E. Raskob, and A. J. Comerota, “Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition),” Chest, vol. 133, no. 6, pp. 454S–545S, 2008. View at Publisher · View at Google Scholar · View at PubMed
  76. S. Pierson, D. Pierson, R. Swallow, and G. Johnson, “Efficacy of graded elastic compression in the lower leg,” JAMA, vol. 249, no. 2, pp. 242–243, 1983. View at Publisher · View at Google Scholar
  77. A. J. Ten Cate-Hoek, H. ten Cate, J. Tordoir, K. Hamulyák, and M. H. Prins, “Individually tailored duration of elastic compression therapy in relation to incidence of the postthrombotic syndrome,” Journal of Vascular Surgery, vol. 52, no. 1, pp. 132–138, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  78. D. N. Kolbach, M. W. Sandbrink, K. Hamulyak, H. A. Neumann, and M. H. Prins, “Non-pharmaceutical measures for prevention of post-thrombotic syndrome,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD004174, 2004. View at Google Scholar
  79. M. H. Musani, F. Matta, A. Y. Yaekoub, J. Liang, R. D. Hull, and P. D. Stein, “Venous compression for prevention of postthrombotic syndrome: a meta-analysis,” American Journal of Medicine, vol. 123, no. 8, pp. 735–740, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  80. S. R. Kahn, H. Shbaklo, S. Shapiro et al., “Effectiveness of compression stockings to prevent the post-thrombotic syndrome (The SOX Trial and Bio-SOX biomarker substudy): a randomized controlled trial,” BMC Cardiovascular Disorders, vol. 7, article 21, 2007. View at Publisher · View at Google Scholar · View at PubMed
  81. T. Benko, E. A. Cooke, M. A. McNally, and R. A. B. Mollan, “Graduated compression stockings: knee length or thigh length,” Clinical Orthopaedics and Related Research, no. 383, pp. 197–203, 2001. View at Google Scholar · View at Scopus