Table of Contents
Thrombosis
Volume 2012, Article ID 987932, 9 pages
http://dx.doi.org/10.1155/2012/987932
Clinical Study

The Role of Dermcidin Isoform 2: A Two-Faceted Atherosclerotic Risk Factor for Coronary Artery Disease and the Effect of Acetyl Salicylic Acid on It

1Sinha Institute of Medical Science & Technology, 288 Kendua Main Road, Garia, Kolkata 700 084, India
2Calcutta Medical College and Hospital, Kolkata 7000 73, India

Received 20 June 2011; Accepted 4 October 2011

Academic Editor: Christian Doutremepuich

Copyright © 2012 Rajeshwary Ghosh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Fuster, J. Badimon, J. H. Chesebro, and J. T. Fallon, “Plaque rupture, thrombosis, and therapeutic implications,” Haemostasis, vol. 26, no. 4, pp. 269–284, 1996. View at Google Scholar · View at Scopus
  2. M. I. Furman, S. E. Benoit, M. R. Barnard et al., “Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease,” Journal of the American College of Cardiology, vol. 31, no. 2, pp. 352–358, 1998. View at Publisher · View at Google Scholar · View at Scopus
  3. F. L. Ruberg and J. Loscalzo, “Prothrombotic determinants of coronary atherothrombosis,” Vascular Medicine, vol. 7, no. 4, pp. 289–299, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Libby, “Prevention and treatment of atherosclerosis,” in Harrison's Principles of Internal Medicine, D. L. Kasper, E. Braunwald, A. S. Fauci, S. Hauser, D. Longo, and J. L. Jameson, Eds., pp. 1430–1433, McGraw–Hill, New York, NY, USA, 2005. View at Google Scholar
  5. A. C. Maritim, R. A. Sanders, and J. B. Watkins III, “Diabetes, oxidative stress, and antioxidants: a review,” Journal of Biochemical and Molecular Toxicology, vol. 17, no. 1, pp. 24–38, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. A. M. Briones and R. M. Touyz, “Oxidative stress and hypertension: current concepts,” Current Hypertension Reports, vol. 12, no. 2, pp. 135–142, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. R. Sowers, M. Epstein, and E. D. Frohlich, “Diabetes, hypertension, and cardiovascular disease an update,” Hypertension, vol. 37, no. 4, pp. 1053–1059, 2001. View at Google Scholar · View at Scopus
  8. P. N. Hopkins, S. C. Hunt, L. L. Wu, G. H. Williams, and R. R. Williams, “Hypertension, dyslipidemia, and insulin resistance: links in a chain or spokes on a wheel?” Current Opinion in Lipidology, vol. 7, no. 4, pp. 241–253, 1996. View at Google Scholar · View at Scopus
  9. A. K. Sinha, S. Bhattacharya, K. Acharya, and S. Mazumder, “Stimulation of nitric oxide synthesis and protective role of insulin in acute thrombosis in vivo,” Life Sciences, vol. 65, no. 25, pp. 2687–2696, 1999. View at Google Scholar · View at Scopus
  10. B. E. Sobel and D. J. Schneider, “Platelet function, coagulopathy, and impaired fibrinolysis in diabetes,” Cardiology Clinics, vol. 22, no. 4, pp. 511–526, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Chakraborty and A. K. Sinha, “The role of insulin as an antithrombotic humoral factor,” BioEssays, vol. 26, no. 1, pp. 91–98, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Ghosh, S. K. Karmohapatra, M. Bhattacharyya, R. Bhattacharya, G. Bhattacharya, and A. K. Sinha, “The appearance of dermcidin isoform 2, a novel platelet aggregating agent in the circulation in acute myocardial infarction that inhibits insulin synthesis and the restoration by acetyl salicylic acid of its effects,” Journal of Thrombosis and Thrombolysis, vol. 31, no. 1, pp. 13–21, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. L. J. Ignarro, R. G. Harbison, K. S. Wood, and P. J. Kadowitz, “Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid,” Journal of Pharmacology and Experimental Therapeutics, vol. 237, no. 3, pp. 893–900, 1986. View at Google Scholar · View at Scopus
  14. R. Ghosh, S. K. Karmohapatra, G. Bhattacharya, and A. Kumar Sinha, “The glucose-induced synthesis of insulin in liver,” Endocrine, vol. 38, no. 2, pp. 294–302, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. F. H. Messerli, B. Williams, and E. Ritz, “Essential hypertension,” Lancet, vol. 370, no. 9587, pp. 591–603, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Chakraborty, G. A. Khan, P. Banerjee, U. Ray, and A. K. Sinha, “Inhibition of human blood platelet aggregation and the stimulation of nitric oxide synthesis by aspirin,” Platelets, vol. 14, no. 7-8, pp. 421–427, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. U. K. Laemmli, “Cleavage of structural proteins during the assembly of the head of bacteriophage T4,” Nature, vol. 227, no. 5259, pp. 680–685, 1970. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Chevallet, S. Luche, and T. Rabilloud, “Silver staining of proteins in polyacrylamide gels,” Nature Protocols, vol. 1, no. 4, pp. 1852–1858, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. D. H. Atha and K. C. Ingham, “Mechanism of precipitation of proteins by polyethylene glycols. Analysis in terms of excluded volume,” Journal of Biological Chemistry, vol. 256, no. 23, pp. 12108–12117, 1981. View at Google Scholar · View at Scopus
  20. D. Perloff, C. Grim, J. Flack et al., “Human blood pressure: determination by sphygmomanometry,” Circulation, vol. 88, no. 5, part 1, pp. 2460–2470, 1993. View at Google Scholar · View at Scopus
  21. L. Jia, C. Bonaventura, J. Bonaventura, and J. S. Stamler, “S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control,” Nature, vol. 380, no. 6571, pp. 221–226, 1996. View at Publisher · View at Google Scholar · View at Scopus
  22. R. D. Cox and C. W. Frank, “Determination of nitrate and nitrite in blood and urine by chemiluminescence,” Journal of Analytical Toxicology, vol. 6, no. 3, pp. 148–152, 1982. View at Google Scholar · View at Scopus
  23. E. Engvall and P. Perlmann, “Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes,” Journal of Immunology, vol. 109, no. 1, pp. 129–135, 1972. View at Google Scholar · View at Scopus
  24. P. Matsudaira, “Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes,” Journal of Biological Chemistry, vol. 262, no. 21, pp. 10035–10038, 1987. View at Google Scholar · View at Scopus
  25. S. Chakraborty, G. A. Khan, S. K. Karmohapatra, R. Bhattacharya, G. Bhattacharya, and A. K. Sinha, “Purification and mechanism of action of “cortexin”, a novel antihypertensive protein hormone from kidney and its role in essential hypertension in men,” Journal of the American Society of Hypertension, vol. 3, no. 2, pp. 119–132, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Zimmerman, U. Paluch, M. Sprinzl, and W. Neupert, “Cell-free synthesis of the mitochondrial ADP/ATP carrier protein of Neurospora crassa,” European Journal of Biochemistry, vol. 99, no. 2, pp. 247–252, 1979. View at Google Scholar · View at Scopus
  27. A. Giaid and D. Saleh, “Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension,” New England Journal of Medicine, vol. 333, no. 4, pp. 214–221, 1995. View at Publisher · View at Google Scholar · View at Scopus
  28. J. B. Smith and A. L. Willis, “Aspirin selectively inhibits prostaglandin production in human platelets,” Nature: New biology, vol. 231, no. 25, pp. 235–237, 1971. View at Google Scholar · View at Scopus
  29. S. K. Karmohapatra, K. Chakraborty, N. N. Kahn, and A. K. Sinha, “The role of nitric oxide in aspirin induced thrombolysis in vitro and the purification of aspirin activated nitric oxide synthase from human blood platelets,” American Journal of Hematology, vol. 82, no. 11, pp. 986–995, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. E. Ferrannini, S. M. Haffner, and M. P. Stern, “Essential hypertension: an insulin-resistant state,” Journal of Cardiovascular Pharmacology, vol. 15, supplement 5, pp. S18–S25, 1990. View at Google Scholar