Thrombosis

Thrombosis / 2012 / Article / Tab 2

Clinical Study

The Role of Dermcidin Isoform 2: A Two-Faceted Atherosclerotic Risk Factor for Coronary Artery Disease and the Effect of Acetyl Salicylic Acid on It

Table 2

Effect of oral ingestion of aspirin on the blood pressures and on the dermcidin levels in hypertensive subjects.

Hypertensive subjects
Before aspirin ingestionAfter aspirin ingestion
Parameters Dermcidin(pmol/mL) Systolic blood pressure (mm of Hg) Diastolic blood pressure (mm of Hg) NO (nmol/h) Dermcidin (pmol/mL) Systolic blood pressure (mm of Hg) Diastolic blood pressure (mm of Hg) NO (nmol/h)

Range43.1–175150–180 85–110 2.9–51115–14075–85
Median981609019.113080

“Pearson " (correlation coefficient) = + 0.924 and = + 0.909 between dermcidin level and systolic and diastolic pressures, respectively, before aspirin ingestion.
“Pearson " (correlation coefficient) = + 0.689 and + 0.846 between dermcidin level and systolic and diastolic pressures, respectively, after the ingestion of aspirin.
The significance ( value) was between dermcidin levels, systolic and diastolic pressures in hypertensive subjects before and after aspirin ingestion as determined by the Mann Whitney test with the medians significantly different.
Hypertensive subjects ( ) were asked to swallow one 150 mg of aspirin with water after having a meal as described in Section 2. Both the blood pressures and dermcidin levels were determined before the ingestion of aspirin and 3 h after the ingestion of the compound.

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