The Role of Dermcidin Isoform 2: A Two-Faceted Atherosclerotic Risk Factor for Coronary Artery Disease and the Effect of Acetyl Salicylic Acid on It

Table 2

Effect of oral ingestion of aspirin on the blood pressures and on the dermcidin levels in hypertensive subjects.

Hypertensive subjects
Before aspirin ingestion					After aspirin ingestion
Parameters	Dermcidin(pmol/mL)	Systolic blood pressure (mm of Hg)	Diastolic blood pressure (mm of Hg)	NO (nmol/h)	Dermcidin (pmol/mL)	Systolic blood pressure (mm of Hg)	Diastolic blood pressure (mm of Hg)	NO (nmol/h)
Range	43.1–175	150–180	85–110	0.4±0.19	2.9–51	115–140	75–85	1.9±0.5
Median	98	160	90		19.1	130	80

“Pearson 𝑟" (correlation coefficient) = + 0.924 and = + 0.909 between dermcidin level and systolic and diastolic pressures, respectively, before aspirin ingestion.
“Pearson 𝑟" (correlation coefficient) = + 0.689 and + 0.846 between dermcidin level and systolic and diastolic pressures, respectively, after the ingestion of aspirin.
The significance (𝑃 value) was 𝑃<0.005 between dermcidin levels, systolic and diastolic pressures in hypertensive subjects before and after aspirin ingestion as determined by the Mann Whitney 𝑈 test with the medians significantly different.
Hypertensive subjects (𝑛=74) were asked to swallow one 150 mg of aspirin with water after having a meal as described in Section 2. Both the blood pressures and dermcidin levels were determined before the ingestion of aspirin and 3 h after the ingestion of the compound.