A Systematic Review of the Utility of Residual Vein Obstruction Studies in Primary and Secondary Venous Thrombosis

Table 1

Characteristics of included studies.

Study	Design	Sites	f/u mos	Age	DAC; (mo)	CUS date	STD	Criteria	Primary; (𝑛)	Secondary; (𝑛)	Proximal; (𝑛)	Distal; (𝑛)	𝑛^∗	RVO+; (𝑛)	RVO−; (𝑛)	RVO+ DVT+; (𝑛)	RVO− DVT+; (𝑛)
Cosmi et al. 2010 [8]	RCT	MC	18	63	≥3	SAC	Video	Prandoni	397	0	397	0	397	151	246	17	32
Siragusa et al. 2011 [14]	RCT	MC	12	55	3–24	3 mo	N/A	Siragusa	409	0	409	0	394	258	136	27	2
Cosmi et al. 2005 [15]	PC	SC	24	72	6	SAC	None	Prandoni	400	0	400	0	400	225	175	41	26
Kearon et al. 1999 [20]	RCT	N/A	24	59	3	SAC	None	+/−	83	0	83	0	81	46	35	8	9
Le Gal et al. 2011 [16]	PC	MC	17	54	5–7	SAC	Yes	+/−	452	0	452	0	451	231	220	45	32
Prandoni et al. 2009 [17]	RCT	MC	36	65	3	SAC	Video	Pradoni	151	117	268	0	268	79	189	19	27
Poli et al. 2008 [22]	PC	SC	25	62	≥3	SAC	None	Pradoni	183	112	295	0	258	105	153	14	18
Young et al. 2006 [23]	PC	SC	33	55	3–6	SAC	None	+/−	103	213	241	72	316	174	142	34	13
Siragusa et al. 2008 [12]	PC	MC	24	60	≥3	N/A	None	Pradoni	100	70	170	0	170	92	78	25	1
Kearon et al. 2004 [21]	RCT	N/A	12	56	≥1	SAC	None	+/−	0	129	88	41	129	45	84	3	3
Cosmi et al. 2011 [19]	PC	SC	24	60.8	5	SAC	N/A	Pradoni	0	296	296	0	294	132	162	9	6
Siragusa et al. 2010 [24]	RCT	N/A	12	59.3	6*	SAC	N/A	Siragusa	0	228	N/A	N/A	228	123	105	27	3
Cosmi et al. 2005 [15]	PC	N/A	24	71	≥3	SAC	N/A	Pradoni	0	88	88	0	88	51	37	16	5

RCT: randomized controlled trial.
PC: prospective cohort/open label.
MC: multicenter.
SC: single center.
+/−: present or absent, normal or abnormal.
STD: standardization method.
f/u: follow-up.
6*: LMWH given for the duration.
SAC: same day as stopping anticoagulation.
𝑛 *: total number eligible for analysis.
N/A: not available.
DAC: duration of anticoagulation.