Study of Associated Genetic Variants in Indian Subjects Reveals the Basis of Ethnicity Related Differences in Susceptibility to Venous Thromboembolism
Table 2
Genotypic and allelic distribution.
Serial number
Gene
Study group
Genotype (frequency)
Allele (frequency)
HWE ( value)
GG
GA
AA
G
A
1
FVL 1691G/A
Control
102 (100)
0
0
204 (100)
0
1.0
Patients
93 (100)
0
0
186 (100)
0
1.0
GG
GA
AA
G
A
2
Prothrombin 20210G/A
Control
102 (100)
0
0
204 (100)
0
1.0
Patients
93 (100)
0
0
186 (100)
0
1.0
CC
CT
TT
C
T
3
TFPI −536C/T
Control
102 (100)
0
0
204 (100)
0
1.0
Patients
93 (100)
0
0
86 (100)
0
1.0
4G
4G/5G
5G
4G
5G
4
PAI-1 −6754G/5G
Control
27 (26.47)
53 (51.96)
22 (21.56)
107 (52.45)
97 (47.75)
0.67
Patients
31 (33.33)
39 (41.93)
23 (24.73)
101 (54.30)
85 (45.69)
0.13
GG
GA
AA
G
A
5
PAI-1 −844G/A
Control
20 (19.6)
68 (66.66)
14 (13.72)
108 (52.94)
112 (60.21)
0.0006
Patients
20 (21.50)
72 (77.41)
1 (1.07)
96 (47.05)
74 (39.78)
0
CC
CT
TT
C
T
6
MTHFR 677C/T
Control
66 (62.04)
36 (34.95)
0
170 (82.52)
36 (17.47)
0.03
Patients
73 (78.49)
18 (19.35)
2 (2.15)
164 (88.17)
22 (11.82)
0.48
AA
AC
CC
A
C
7
MTHFR 1298A/C
Control
18 (16.66)
84 (82.35)
0
120 (58.82)
84 (41.17)
0
Patients
31 (33.33)
62 (66.66)
0
124 (66.66)
62 (33.33)
0
CC
CT
TT
C
T
8
Fibrinogen-β 148C/T
Control
52 (50.98)
45 (44.11)
5 (4.90)
149 (73.03)
55 (26.96)
0.22
Patients
53 (56.98)
38 (40.86)
2 (2.15)
144 (77.41)
42 (22.58)
0.10
GG
GA
AA
G
A
9
Fibrinogen-β −455 G/A
Control
71 (69.60)
24 (23.52)
7 (6.86)
166 (81.37))
38 (18.62)
0.02
Patients
62 (69.66)
27 (30.33)
0
151 (84.83)
27 (15.16)
0.09
Observed frequency distribution of genotypic and allelic frequencies in the control () and patients () group along with HWE calculation. The value lesser than 0.05 was the criteria for significance for all statistical tests.
