Thrombosis

Thrombosis / 2014 / Article / Tab 2

Research Article

Study of Associated Genetic Variants in Indian Subjects Reveals the Basis of Ethnicity Related Differences in Susceptibility to Venous Thromboembolism

Table 2

Genotypic and allelic distribution.

Serial numberGeneStudy groupGenotype (frequency)Allele (frequency)HWE ( value)

GGGAAAGA

1FVL
1691G/A
Control102 (100)00204 (100)01.0
Patients93 (100)00186 (100)01.0

GGGAAAGA

2Prothrombin 20210G/AControl102 (100)00204 (100)01.0
Patients93 (100)00186 (100)01.0

CCCTTTCT

3TFPI
−536C/T
Control102 (100)00204 (100)01.0
Patients93 (100)0086 (100)01.0

4G4G/5G5G4G5G

4PAI-1
−6754G/5G
Control27 (26.47)53 (51.96)22 (21.56)107 (52.45)97 (47.75)0.67
Patients31 (33.33)39 (41.93)23 (24.73)101 (54.30)85 (45.69)0.13

GGGAAAGA

5PAI-1
−844G/A
Control20 (19.6)68 (66.66)14 (13.72)108 (52.94)112 (60.21)0.0006
Patients20 (21.50)72 (77.41)1 (1.07)96 (47.05)74 (39.78)0

CCCTTTCT

6MTHFR
677C/T
Control66 (62.04)36 (34.95)0170 (82.52)36 (17.47)0.03
Patients73 (78.49)18 (19.35)2 (2.15)164 (88.17)22 (11.82)0.48

AAACCCAC

7MTHFR
1298A/C
Control18 (16.66)84 (82.35)0120 (58.82)84 (41.17)0
Patients31 (33.33)62 (66.66)0124 (66.66)62 (33.33)0

CCCTTTCT

8Fibrinogen-β
148C/T
Control52 (50.98)45 (44.11)5 (4.90)149 (73.03)55 (26.96)0.22
Patients53 (56.98)38 (40.86)2 (2.15)144 (77.41)42 (22.58)0.10

GGGAAAGA

9Fibrinogen-β
−455 G/A
Control71 (69.60)24 (23.52)7 (6.86)166 (81.37))38 (18.62)0.02
Patients62 (69.66)27 (30.33)0151 (84.83)27 (15.16)0.09

Observed frequency distribution of genotypic and allelic frequencies in the control () and patients () group along with HWE calculation. The value lesser than 0.05 was the criteria for significance for all statistical tests.