Thrombosis

Thrombosis / 2014 / Article / Tab 3

Research Article

Study of Associated Genetic Variants in Indian Subjects Reveals the Basis of Ethnicity Related Differences in Susceptibility to Venous Thromboembolism

Table 3

Statistical analysis for polymorphic SNPs.

Gene (df = 2) valueFischer’s exactORCI

PAI-1 −6754G/5G2.010.360.760.920.62–1.38
PAI-1 −844 G/A10.990.0040.150.740.49–1.11
MTHFR 677C/T7.70.020.120.630.35–1.12
MTHFR 1298A/C000.110.710.47–1.08
Fibrinogen-  −455G/A6.930.030.410.780.45–1.34
Fibrinogen-β 148C/T1.470.470.340.790.49–1.25

Statistical tests of SNPs in candidate genes. test and observed values show significant difference in MTHFR C677T, PAI −844 G/A, and fibrinogen-β chain −455G/A SNPs (). No SNP showed significant allelic difference between patients and control group (Fisher’s exact >0.05). The value lesser than 0.05 was the criteria for significance for all statistical tests.