Review Article

Medicinal Herbals with Antiplatelet Properties Benefit in Coronary Atherothrombotic Diseases

Table 1

Summary of inhibition of platelet activation by medicinal herbs.

ReferencePlantsCompoundDose of plants’ extract Agonist and dosagePostulated antiplatelet properties In vivo or in vitro

[68]Turmeric (Curcuma longa)Ar-turmerone, curcumin100 µg/ml, 500 µMCollagen (2 µg/ml), ADP (10 µM), and thrombin (0.64 U/ml)Adhesion In vivo

[12, 13]Barberry (Berberis vulgaris)Berberine30 mg/kgCollagenAdhesion In vivo

[14]Osmanthus fragrans2.8 mg/mlCollagen (1 mg/ml) and ADP (5 mM)Adhesion, secretionIn vitro

[15]Magnolia (Magnolia officinalis) Magnolol, honokiolCollagen (10 µg/ml)AdhesionIn vitro

[16]Cudrania tricuspidata BureauCudratricusxanthone A10 µMThrombin (3 U/ml) AggregationIn vitro

[17, 18]Dong quai (Angelica sinensis)Z-Ligustilide40 mg/kgADP (5 µM)SecretionIn vivo

[1922]Ginger (Zingiber officinale)Gingerol, paradol25 µM AA (20 mM) and AA (2 µM)SecretionIn vitro

[23, 24]Garlic (Allium sativum)Methanol extract48–95 g/kgADP (10 µM), epinephrine (10 µg/ml), collagen (2 µg/ml), thrombin (0.1 U/ml), AA (1.1 mM), and PAF (10 µM)Adhesion, secretion, and aggregationIn vitro, in vivo

[2527]Scutellaria baicalensis GeorgiBaicalin, wogonoside45.6 µM, 30 µMThrombin (3 U/ml), collagen (1 µg/ml), and ADP (5 µM)Adhesion, secretionIn vitro

[2830]Fructus gardeniaIridoid glycosides, genipin100 mg/kCollagen (1 µg/ml)Adhesion, vasoconstrictionIn vivo