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Tuberculosis Research and Treatment
Volume 2010, Article ID 517547, 8 pages
Research Article

Decreased Expression of T-Cell Costimulatory Molecule CD28 on CD4 and CD8 T Cells of Mexican Patients with Pulmonary Tuberculosis

1Facultad de Farmacia, Universidad Autonoma del Estado de Morelos, 62209 Morelos, Mexico
2Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Apartado Postal 70228 Ciudad Universitaria, 04510, Mexico City, Mexico

Received 25 January 2010; Revised 1 July 2010; Accepted 19 July 2010

Academic Editor: Robert S. Wallis

Copyright © 2010 German Bernal-Fernandez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Patients with tuberculosis frequently develop anergy, a state of T-cell hyporesponsiveness in which defective T-cell costimulation could be a factor. To know if the expression of T-cell costimulatory molecules was altered in tuberculosis, we analyzed the peripheral blood T-cell phenotype of 23 Mexican patients with pulmonary tuberculosis. There was severe CD4 ( 𝑃 < . 0 0 1 ) and CD8 ( 𝑃 < . 0 1 ) lymphopenia and upregulation of costimulatory molecule CD30 on CD4 and CD8 T cells ( 𝑃 < . 0 5 ); this increase was higher in relapsing tuberculosis. The main finding was severe downregulation of the major costimulatory molecule CD28 on both CD8 and CD4 T cells ( 𝑃 < . 0 0 1 ). Depletion of the CD4/CD28 subset, a hitherto undescribed finding, is relevant because CD4 T cells constitute the main arm of the cell-mediated antimycobacterial immune response.