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Tuberculosis Research and Treatment
Volume 2011 (2011), Article ID 986409, 6 pages
http://dx.doi.org/10.1155/2011/986409
Research Article

Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis

1Grupo de Química Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Carrera 53 No. 61-30, Laboratorio 234, Medellín 50010, Colombia
2Grupo Micobacterias, Instituto Nacional de Salud, Bogotá 11001, D.C., Colombia
3Grupo de Inmunología y Epidemiología Molecular, Universidad Industrial de Santander, Bucaramanga 68001, Colombia
4Grupo Microscopia y Análisis de Imágenes, Instituto Nacional de Salud, Bogotá 11001, D.C., Colombia

Received 26 November 2010; Revised 28 January 2011; Accepted 16 February 2011

Academic Editor: Brian Eley

Copyright © 2011 Eduard Baquero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology.