Tuberculin Skin Tests versus Interferon-Gamma Release Assays in Tuberculosis Screening among Immigrant Visa Applicants
Table 6
Subject characteristics associated with CXR and TST discordance.
Characteristic
CXR positive but TST negative
CXR negative but TST positive
aOR* (95% CI)
aOR* (95% CI)
Total
1163**
79
501
Age group in years
18–20 yrs
130
6 (4.6%)
1.0
42 (32.3%)
1.0
21–30 yrs
270
3 (1.1%)
0.23 (0.06–0.94)
120 (44.4%)
1.90 (1.22–2.98)
31–40 yrs
279
7 (2.5%)
0.53 (0.17–1.59)
161 (57.7%)
2.91 (1.87–4.53)
41–50 yrs
252
19 (7.5%)
1.59 (0.62–4.11)
103 (40.9%)
1.54 (0.98–2.42)
51–64 yrs
189
32 (16.9%)
3.88 (1.57–9.62)
69 (36.5%)
1.38 (0.85–2.25)
≥65 yrs
43
12 (27.9%)
6.76 (2.31–19.79)
6 (14.0%)
0.39 (0.15–1.004)
Sex
Female
781
51 (6.5%)
324 (41.5%)
1.0
Male
382
28 (7.3%)
N.S. and NIM
177 (46.3%)
1.33 (1.03–1.73)
Other major medical conditions
No
1146
72 (6.3%)
1.0
497 (43.4%)
Yes
17
7 (41.2%)
4.52 (1.58–12.96)
4 (23.5%)
N.S. and NIM
BCG status
Not vaccinated
684
58 (8.5%)
253 (37.0%)
1.0
Vaccinated
479
21 (4.4%)
N.S. and NIM
248 (51.8%)
1.61 (1.25–2.07)
M. avium reactivity
No
812
58 (7.1%)
369 (45.4%)
1.0
Yes
351
21 (6.0%)
N.S. and NIM
132 (37.5%)
0.71 (0.54–0.93)
CXR: chest radiograph; TST: tuberculin skin test; : number in subset of ; aOR: adjusted odd ratio; 95% CI: 95% confidence interval; N.S.: not significant; NIM: not in model; BCG: bacille Calmitte-Guérin; QFT: QuantiFERON-TB test.
*Multivariate models were created using factors with values ≤0.2 in univariate analysis and <0.05 in stepwise logistic regression until the best fitting, parsimonious model was identified. Model fit was evaluated using the Hosmer-Lemeshow test. Bold font indicates statistically significant adjusted odds ratios (aORs).
**Data from 83 subjects with indeterminate QFT-G results were excluded from analysis.
