Tuberculosis Research and Treatment / 2014 / Article / Tab 2

Clinical Study

Adverse Reactions to Antituberculosis Drugs in Iranian Tuberculosis Patients

Table 2

Associated risk factors for major adverse drug reactions due to anti-TB drugs.

VariablesWithout ADRs 671 (100%)With major ADRs 54 (100%)Adjusted odds ratio (95% CI) value

Age (years)
 ≥50296 (44.1)33 (61.1)1.99 (1.13–3.51)0.0223
 <50375 (55.9)21 (38.9)
Gender
 Female327 (47.8)35 (64.8)1.94 (1.09–3.46)0.0241
 Male344 (51.3)19 (35.2)
Location
 Urban382 (56.9)30 (55.6)0.94 (0.54–1.65)0.8868
 Rural289 (43.1)24 (44.4)
Nationality
 Iranian522 (77.8)49 (90.7)2.79 (1.10–7.15)0.0362
 Immigrant (Afghans)149 (22.2)5 (9.3)
HIV status
 HIV+7 (1.1)3 (5.6)5.58 (1.40–22.23)0.0323
 HIV−664 (98.9)51 (94.4)
Smoking
 Smoker112 (16.7)19 (35.2)2.71 (1.43–5.09)0.002
 Nonsmoker559 (83.3)35 (64.8)
Addiction
 Addict24 (3.6)5 (9.3)0.36 (0.13–0.99)0.0569
 Nonaddicts647 (96.4)49 (90.7)
Diagnosis delay
 ≤30 days269 (40.1)23 (42.6)0.90 (0.52–1.58)0.7735
 >30 days402 (59.9)31 (57.4)
TB treatment history
 Primary660 (98.4)50 (92.6)4.8 (1.48–15.62)0.0203
 Retreatment11 (1.6)4 (7.4)
Type of TB
 Pulmonary509 (75.9)36 (66.7)0.64 (0.35–1.15)0.1416
 Nonpulmonary162 (24.1)18 (33.3)
Comorbidity (except HIV)
 Yes160 (23.9)25 (46.3)2.75 (1.57–4.84)0.0005
 No511 (76.1)29 (53.7)
Grading of sputum smear
 <2+129 (39.7)11 (33.3)0.76 (0.36–1.62)0.5756
 ≥2+196 (60.3)22 (66.7)

Diagnostic delay: time interval between the onset of symptoms and labelling of the patient as a tuberculosis patient.
WHO grading scale for AFB found by Ziehl-Neelsen smear microscopy:scanty, 1+, 2+, and 3+.