Mefloquine and Its Enantiomers Are Active against Mycobacterium tuberculosis In Vitro and in Macrophages

Table 2

Activity of mefloquine, (+)erythro-mefloquine, and (−)erythro-mefloquine against H37Rv, Erdman and MDR-TB strains in oxygen-depleted environment (NRB) in vitro (Wayne model).

Bacteria strain	MIC (mcg/mL)
	Mefloquine	(+)Erythro-mefloquine	(−)Erythro-mefloquine
H37Rv	8	8	8
Edman	8	8	8
MDR Mtb 368 (Brazil)	8	8	8
MDR Mtb 400 (Asia)	8	8	8

Conditions obtained using the Wayne system.