Tuberculosis Research and Treatment / 2016 / Article / Tab 1

Research Article

Molecular and Growth-Based Drug Susceptibility Testing of Mycobacterium tuberculosis Complex for Ethambutol Resistance in the United States

Table 1

Comparison of PHL growth-based DST with CDC’s molecular detection and growth-based DST results for EMB.

PHL growth-based DST result for EMBCDC molecular result for embB (amino acid change)CDC’s agar proportion result (number of MTBC samples)
ResistantSusceptibleNo growthContaminatedTotal number of samples

ResistantMet306Ile40307
Met306Ile, Asp328Gly00101
Met306Ile, Gly406Ala10001
Met306Val903113
Phe330Leu10001
Tyr334His20002
Ser347Thr10001
Asp354Ala20103
Glu378Ala01001
Gly406Ala20002
Gly406Asp10001
No mutation43018
Not performed20002

SusceptibleGly294Gly01001
Asn296Tyr10001
Met306Ile21104
Met306Val40004
Val309Ile00101
Leu355Leu01001
Leu355Leu, Glu378Ala03003
Glu378Ala094215
Gly406Ala02002
Gly406Cys21003
Gly406Ser10001
No mutation610529122
Not performed090110

Total451361614211

PHL: public health laboratory; DST: drug susceptibility testing; CDC: Centers for Disease Control and Prevention; EMB: ethambutol; MTBC: Mycobacterium tuberculosis complex.

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