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Tuberculosis Research and Treatment
Volume 2016 (2016), Article ID 4282313, 6 pages
http://dx.doi.org/10.1155/2016/4282313
Research Article

The Use of Xpert MTB/Rif for Active Case Finding among TB Contacts in North West Province, South Africa

1Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg 2000, South Africa
2Public Health, School of Medicine, University of Liverpool, Liverpool L69 7ZX, UK
3Department of Molecular Medicine and Hematology, University of the Witwatersrand, Johannesburg 2000, South Africa
4Department of Internal Medicine, Klerksdorp/Tshepong Hospital Complex, North West Department of Health and University of the Witwatersrand, Johannesburg 2000, South Africa
5DST/NRF Centre of Excellence for Biomedical TB Research, University of the Witwatersrand, Johannesburg 2000, South Africa

Received 30 April 2016; Accepted 16 June 2016

Academic Editor: Brian Eley

Copyright © 2016 Limakatso Lebina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. World Health Organization, “Global Tuberculosis Report 2014,” WHO report 2014, http://apps.who.int/iris/bitstream/10665/137094/1/9789241564809_eng.pdf.
  2. World Health Organization, “The Top Ten Causes of Death,” Fact Sheet 310, World Health Organization, Geneva, Switzerland, 2013, http://www.who.int/mediacentre/factsheets/fs310/en/index.html. View at Google Scholar
  3. World Health Organization, “South Africa tuberculosis profile,” WHO Report, World Health Organization, Geneva, Switzerland, 2012, http://www.who.int/tb/country/data/profiles/en/. View at Google Scholar
  4. UNAIDS, “South Africa HIV and AIDS Estimates—2011,” UNAIDS 2012 Report, http://www.unaids.org/en/regionscountries/countries/southafrica/.
  5. M. S. Jassal and W. R. Bishai, “Epidemiology and challenges to the elimination of global tuberculosis,” Clinical Infectious Diseases, vol. 50, supplement 3, pp. S156–S164, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. J. E. Golub, C. I. Mohan, G. W. Comstock, and R. E. Chaisson, “Active case finding of tuberculosis: historical perspective and future prospects,” The International Journal of Tuberculosis and Lung Disease, vol. 9, no. 11, pp. 1183–1203, 2005. View at Google Scholar · View at Scopus
  7. A. Van Rie, L. Page-Shipp, L. Scott, I. Sanne, and W. Stevens, “Xpert® MTB/RIF for point-of-care diagnosis of TB in high-HIV burden, resource-limited countries: hype or hope?” Expert Review of Molecular Diagnostics, vol. 10, no. 7, pp. 937–946, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. S. D. Lawn and M. P. Nicol, “Xpert® MTB/RIF assay: development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance,” Future Microbiology, vol. 6, no. 9, pp. 1067–1082, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. World Health Organization, Tuberculosis Diagnostics Automated DNA Test. WHO Endorsement and Recommendations, World Health Organization, Geneva, Switzerland, 2010, http://www.who.int/tb/features_archive/xpert_factsheet.pdf.
  10. A. E. Shapiro, E. Variava, M. H. Rakgokong et al., “Community-based targeted case finding for tuberculosis and HIV in household contacts of patients with tuberculosis in South Africa,” American Journal of Respiratory and Critical Care Medicine, vol. 185, no. 10, pp. 1110–1116, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. R. M. Pronyk, B. Joshi, R. J. Hargreaves et al., “Active case finding: understanding the burden of tuberculosis in rural South Africa,” International Journal of Tuberculosis and Lung Disease, vol. 5, no. 7, pp. 611–618, 2001. View at Google Scholar · View at Scopus
  12. D. Thind, S. Charalambous, A. Tongman, G. Churchyard, and A. D. Grant, “An evaluation of ‘Ribolola’: a household tuberculosis contact tracing programme in North West Province, South Africa,” The International Journal of Tuberculosis and Lung Disease, vol. 16, no. 12, pp. 1643–1648, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. S. E. Dorman, V. N. Chihota, J. J. Lewis et al., “Performance characteristics of the cepheid Xpert MTB/RIF test in a tuberculosis prevalence survey,” PLoS ONE, vol. 7, no. 8, Article ID e43307, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. C. C. Boehme, M. P. Nicol, P. Nabeta et al., “Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study,” The Lancet, vol. 377, no. 9776, pp. 1495–1505, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Meyer-Rath, K. Schnippel, L. Long et al., “The impact and cost of scaling up genexpert MTB/RIF in South Africa,” PLoS ONE, vol. 7, no. 5, Article ID e36966, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Vassall, S. van Kampen, H. Sohn et al., “Rapid diagnosis of tuberculosis with the Xpert MTB/RIF assay in high burden countries: a cost-effectiveness analysis,” PLoS Medicine, vol. 8, no. 11, Article ID e1001120, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Theron, A. Pooran, J. Peter et al., “Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting?” European Respiratory Journal, vol. 40, no. 1, pp. 161–168, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Kranzer, S. D. Lawn, G. Meyer-Rath et al., “Feasibility, yield, and cost of active tuberculosis case finding linked to a mobile hiv service in cape town, south africa: a cross-sectional study,” PLoS Medicine, vol. 9, no. 8, Article ID e1001281, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. Human Science Research Council (HSRC), “South African National HIV prevalence, incidence, behaviour and communication survey,” HSRC 2008 Report, 2009. View at Google Scholar
  20. A. Zumla, M. Raviglione, R. Hafner, and C. F. Von Reyn, “Tuberculosis,” The New England Journal of Medicine, vol. 368, no. 8, pp. 745–755, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. World Health Organization, Recommendations for Investigating Contacts of Persons with Infectious Tuberculosis in Low- and Middle Income Countries, World Health Organization, Geneva, Switzerland, 2013.
  22. G. Chamie, A. Luetkemeyer, E. Charlebois, and D. V. Havlir, “Tuberculosis as part of the natural history of HIV infection in developing countries,” Clinical Infectious Diseases, vol. 50, supplement 3, pp. S245–S254, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. C. J. Hoffmann, E. Variava, M. Rakgokong et al., “High prevalence of pulmonary tuberculosis but low sensitivity of symptom screening among HIV-infected pregnant women in South Africa,” PLoS ONE, vol. 8, no. 4, Article ID e62211, 2013. View at Publisher · View at Google Scholar · View at Scopus