Tuberculosis Research and Treatment / 2017 / Article / Tab 1

Review Article

Nanotechnology-Based Approach in Tuberculosis Treatment

Table 1

TB drugs development in pipeline.

DiscoveryPreclinical development Clinical development
Phase 1Phase 2Phase 3

Existing drugs redeveloped or repurposed for TBLinezolid, rifapentineGatifloxacin, moxifloxacin

New drugs developed specifically for TBNitroimidazole, riminophenazines, translocase-1 inhibitor, InhA inhibitor, GyrB inhibitor, LueRS inhibitor, pyrazinamide analogues, diarylquinoline, spectinamidesCPZEN-45, SQ641, SQ609, DC159a, Q201AZD5847Bedaquiline (TMC-207), PA-824, SQ-109, PNU-100480Delamanid (OPC67683)

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