The Scientific World Journal

The Scientific World Journal / 2001 / Article
Special Issue

Collection of Directions in Science Articles from TheScientificWorldJOURNAL

View this Special Issue

Directions in Science | Open Access

Volume 1 |Article ID 230940 | https://doi.org/10.1100/tsw.2001.359

Jennifer E. Fox, Matthew E. Burow, John A. McLachlan, "Symbiotic Gene Activation is Interrupted by Endocrine Disrupting Chemicals", The Scientific World Journal, vol. 1, Article ID 230940, 3 pages, 2001. https://doi.org/10.1100/tsw.2001.359

Symbiotic Gene Activation is Interrupted by Endocrine Disrupting Chemicals

Academic Editor: Lawrence A. Frohman

Abstract

Endocrine disrupting chemicals (EDCs) include organochlorine pesticides, plastics manufacturing by-products, and certain herbicides[1]. These chemicals have been shown to disrupt hormonal signaling in exposed wildlife, lab animals, and mammalian cell culture by binding to estrogen receptors (ER-α and ER-β) and affecting the expression of estrogen responsive genes[2,3]. Additionally, certain plant chemicals, termed phytoestrogens, are also able to bind to estrogen receptors and modulate gene expression, and as such also may be considered EDCs[4]. One example of phytoestrogen action is genistein, a phytochemical produced by soybeans, binding estrogen receptors, and changing expression of estrogen responsive genes which certain studies have linked to a lower incidence of hormonally related cancers in Japanese populations[5]. Why would plants make compounds that are able to act as estrogens in the human body? Obviously, soybeans do not intentionally produce phytoestrogens to prevent breast cancer in Japanese women.


More related articles

 PDF Download Citation Citation
 Order printed copiesOrder
Views95
Downloads365
Citations

Related articles