The Scientific World Journal

The Scientific World Journal / 2001 / Article
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Collection of Directions in Science Articles from TheScientificWorldJOURNAL

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Directions in Science | Open Access

Volume 1 |Article ID 316964 | 2 pages | https://doi.org/10.1100/tsw.2001.27

A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses

Abstract

Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world [1]. This common bacterium produces a toxin known as cytolethal distending toxin (CDT) [2] which causes intoxicated cells to enlarge and to stop dividing with a double DNA content characteristic of G2/M arrest [3]. The effect of the toxin on the cell is so striking that it captivated scientists for a long time. However, its mechanism of action had remained elusive.


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