The Scientific World Journal

The Scientific World Journal / 2001 / Article
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Volume 1 |Article ID 316964 |

Maria Lara-Tejero, "A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses", The Scientific World Journal, vol. 1, Article ID 316964, 2 pages, 2001.

A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses


Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world [1]. This common bacterium produces a toxin known as cytolethal distending toxin (CDT) [2] which causes intoxicated cells to enlarge and to stop dividing with a double DNA content characteristic of G2/M arrest [3]. The effect of the toxin on the cell is so striking that it captivated scientists for a long time. However, its mechanism of action had remained elusive.

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