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A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses
Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world . This common bacterium produces a toxin known as cytolethal distending toxin (CDT)  which causes intoxicated cells to enlarge and to stop dividing with a double DNA content characteristic of G2/M arrest . The effect of the toxin on the cell is so striking that it captivated scientists for a long time. However, its mechanism of action had remained elusive.