The Scientific World Journal

The Scientific World Journal / 2001 / Article
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Volume 1 |Article ID 492635 | https://doi.org/10.1100/tsw.2001.35

Todd B. Sherer, Ranjita Betarbet, J. Timothy Greenamyre, "Pesticides and Parkinson’s Disease", The Scientific World Journal, vol. 1, Article ID 492635, 2 pages, 2001. https://doi.org/10.1100/tsw.2001.35

Pesticides and Parkinson’s Disease

Abstract

Parkinson’s disease (PD), a common neurodegenerative disorder affects approximately 1% of the population over 65. PD is a late-onset progressive motor disease characterized by tremor, rigidity (stiffness), and bradykinesia (slowness of movement). The hallmark of PD is the selective death of dopamine-containing neurons in the substantia nigra pars compacta which send their projections to the striatum and the presence of cytoplasmic aggregates called Lewy bodies [1-2]. Most cases of PD are sporadic but rare cases are familial, with earlier onset. The underlying mechanisms and causes of PD still remain unclear.


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