The Scientific World Journal

The Scientific World Journal / 2001 / Article
Special Issue

Collection of Directions in Science Articles from TheScientificWorldJOURNAL

View this Special Issue

Directions in Science | Open Access

Volume 1 |Article ID 580242 | 3 pages | https://doi.org/10.1100/tsw.2001.254

ASIC3: A Lactic Acid Sensor for Cardiac Pain

Academic Editor: Edward G. Jones

Abstract

Angina, the prototypic vasoocclusive pain, is a radiating chest pain that occurs when heart muscle gets insufficient blood because of coronary artery disease. Other examples of vasoocclusive pain include the acute pain of heart attack and the intermittent pains that accompany sickle cell anemia and peripheral artery disease. All these conditions cause ischemia � insufficient oxygen delivery for local metabolic demand — and this releases lactic acid as cells switch to anaerobic metabolism. Recent discoveries demonstrate that sensory neurons innervating the heart are richly endowed with an ion channel that is opened by, and perfectly tuned for, the lactic acid released by muscle ischemia[1,2].


More related articles

129 Views | 1372 Downloads | 45 Citations
 PDF  Download Citation  Citation
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.