The Scientific World Journal

The Scientific World Journal / 2001 / Article

Mini-Review Article | Open Access

Volume 1 |Article ID 914679 | https://doi.org/10.1100/tsw.2001.297

Christine Latif, Susan H. Harvey, Susan J. O'Connell, "Ensuring the Stability of the Genome: DNA Damage Checkpoints", The Scientific World Journal, vol. 1, Article ID 914679, 19 pages, 2001. https://doi.org/10.1100/tsw.2001.297

Ensuring the Stability of the Genome: DNA Damage Checkpoints

Academic Editor: William J. Manning

Abstract

The cellular response to DNA damage is vital for the cell�s ability to maintain genomic integrity. Checkpoint signalling pathways, which induce a cell cycle arrest in response to DNA damage, are an essential component of this process. This is reflected by the functional conservation of these pathways in all eukaryotes from yeast to mammalian cells. This review will examine the cellular response to DNA damage throughout the cell cycle. A key component of the DNA damage response is checkpoint signalling, which monitors the state of the genome prior to DNA replication (G1/S) and chromosome segregation (G2/M). Checkpoint signalling in model systems including mice, Xenopus laevis, Drosophila melanogaster, and the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have been useful in elucidating these pathways in mammalian cells. An examination of this research, with emphasis on the function of checkpoint proteins, their relationship to DNA repair, and their involvement in oncogenesis is undertaken here.


More related articles

 PDF Download Citation Citation
 Order printed copiesOrder
Views219
Downloads748
Citations

Related articles

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.