The Scientific World Journal

The Scientific World Journal / 2002 / Article

Review Article | Open Access

Volume 2 |Article ID 185316 |

Mirna Mourtada-Maarabouni, Gwyn T. Williams, "RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?", The Scientific World Journal, vol. 2, Article ID 185316, 6 pages, 2002.

RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?

Received19 Mar 2002
Revised17 May 2002
Accepted17 May 2002


The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene.

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