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TheScientificWorldJOURNAL
Volume 2 (2002), Pages 1885-1890
http://dx.doi.org/10.1100/tsw.2002.859
Review Article

RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?

School of Life Sciences, Keele University, Keele, Staffs, ST5 5BG, UK

Received 19 March 2002; Revised 17 May 2002; Accepted 17 May 2002

Copyright © 2002 Mirna Mourtada-Maarabouni and Gwyn T. Williams.

Abstract

The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene.