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Volume 2, Pages 690-700
Review Article

Formation of Neural Precursor Cell Populations by Differentiation of Embryonic Stem Cells In Vitro

1Department of Molecular Biosciences, Adelaide University, Australia
2ARC SRC for Molecular Genetics of Development, Adelaide University, Australia

Received 15 October 2001; Revised 20 December 2001; Accepted 15 January 2002

Copyright © 2002 Joy Rathjen and Peter D. Rathjen.


Recent interest in the generation of neural lineages by differentiation of embryonic stem cells arises from the opportunities represented by a developmentally normal, unlimited source of material that can be manipulated genetically with precision. Several experimental approaches, which differ conceptually, in the route of differentiation and the characteristics of the resulting cell population have been reported. In this review we undertake a comparative analysis of these approaches and their suitability for experimental investigation or implantation.