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Volume 2, Pages 1186-1195
Review Article

Regulation of Apoptosis in African Swine Fever Virus–Infected Macrophages

Plum Island Animal Disease Center, USDA, ARS, P.O.Box 848, Greenport, NY 11944, USA

Received 13 February 2002; Revised 10 March 2002; Accepted 14 March 2002

Copyright © 2002 Laslo Zsak and John G. Neilan.


A number of viruses have evolved antiapoptotic mechanisms to promote infected-cell survival, either to ensure efficient productive viral replication or to promote long-term survival of virus-infected cells. Recent studies identified critical African swine fever virus genes involved in the complex regulation of ASFV-host interactions. Here we review the present knowledge of the recently identified ASFV genes with special attention to those which affect viral virulence, host range, and pathogenesis by regulating viral-induced apoptotic mechanisms.