The Scientific World Journal

The Scientific World Journal / 2002 / Article

Mini-Review Article | Open Access

Volume 2 |Article ID 712791 | 6 pages | https://doi.org/10.1100/tsw.2002.95

Receptor-Mediated Gene Delivery

Received25 Oct 2001
Revised03 Dec 2001
Accepted07 Dec 2001

Abstract

Receptor-mediated gene delivery capitalises on the presence of specific cell surface molecules for DNA uptake into cells and represents a particularly appealing approach for targeting vector DNA to specific cell types in vivo and in vitro. Various ligand/DNA and antibody/DNA transfer complexes were generated that, following binding to cells, are internalised and reach the endosomal compartment. Vector complexes contain endosomolytic components that ensure vector release from the endosome and translocation of vector DNA into the nucleus where transcription occurs. Thus, receptor-mediated gene delivery encompasses several critical steps that must be considered when designing and applying such vector systems.


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