Mini-Review Article | Open Access
Jeffrey D. Axelrod, Helen McNeill, "Coupling Planar Cell Polarity Signaling to Morphogenesis", The Scientific World Journal, vol. 2, Article ID 787516, 21 pages, 2002. https://doi.org/10.1100/tsw.2002.105
Coupling Planar Cell Polarity Signaling to Morphogenesis
Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical–basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymmetry. Most of what is known about PCP derives from studies in the fruit fly, Drosophila. We review what is known about how cells translate an unknown signal into asymmetric cytoskeletal reorganization. We then discuss how the vertebrate processes of convergent extension and cochlear hair-cell development may relate to Drosophila PCP signaling.