The Scientific World Journal

The Scientific World Journal / 2002 / Article

Mini-Review Article | Open Access

Volume 2 |Article ID 787516 |

Jeffrey D. Axelrod, Helen McNeill, "Coupling Planar Cell Polarity Signaling to Morphogenesis", The Scientific World Journal, vol. 2, Article ID 787516, 21 pages, 2002.

Coupling Planar Cell Polarity Signaling to Morphogenesis

Received07 Nov 2001
Revised06 Dec 2001
Accepted14 Dec 2001


Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical–basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymmetry. Most of what is known about PCP derives from studies in the fruit fly, Drosophila. We review what is known about how cells translate an unknown signal into asymmetric cytoskeletal reorganization. We then discuss how the vertebrate processes of convergent extension and cochlear hair-cell development may relate to Drosophila PCP signaling.

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