Table of Contents Author Guidelines Submit a Manuscript
TheScientificWorldJOURNAL
Volume 2, Pages 169-204
http://dx.doi.org/10.1100/tsw.2002.81
Review Article

Lipid-Derived Mediators in Endogenous Anti-Inflammation and Resolution: Lipoxins and Aspirin-Triggered 15-epi-Lipoxins

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA

Received 7 September 2001; Revised 31 October 2001; Accepted 2 November 2001

Copyright © 2002 Charles N. Serhan and Nan Chiang.

Citations to this Article [45 citations]

The following is the list of published articles that have cited the current article.

  • N Chiang, S Watanabe, T Takano, Cn Serhan, and M Arita, “A novel rat lipoxin A(4) receptor that is conserved in structure and function,” British Journal Of Pharmacology, vol. 139, no. 1, pp. 89–98, 2003. View at Publisher · View at Google Scholar
  • Cn Serhan, Rl Moussignac, K Gronert, M Arita, G Bannenberg, Pr Devchand, and S Hong, “Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense,” Faseb Journal, vol. 17, no. 6, pp. 652–659, 2003. View at Publisher · View at Google Scholar
  • Ed Phillips, Hf Chang, Cr Holmquist, and Jp McCauley, “Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, an analogue of 15R-lipoxin A(4),” Bioorganic & Medicinal Chemistry Letters, vol. 13, no. 19, pp. 3223–3226, 2003. View at Publisher · View at Google Scholar
  • C. Bonnans, P. Chanez, and C. Chavis, “Lipoxins in asthma: potential therapeutic mediators on bronchial inflammation?,” Allergy, vol. 59, no. 10, pp. 1027–1041, 2004. View at Publisher · View at Google Scholar
  • Anna Nicolaou, George Kokotos, and Stefano Fiore, “Leukotrienes and lipoxins,” Bioactive lipids, pp. 223–243, 2004. View at Publisher · View at Google Scholar
  • S Fiore, G Antico, M Aloman, and S Sodin-Semrl, “Lipoxin A(4) biology in the human synovium. Role of the ALX signaling pathways in modulation of inflammatory arthritis,” Prostaglandins Leukotrienes And Essential Fatty Acids, vol. 73, no. 3-4, pp. 189–196, 2005. View at Publisher · View at Google Scholar
  • D Mitchell, B McMahon, K Rodgers, C Godson, and D Sadlier, “Lipoxin A(4) modifies platelet-derived growth factor-induced profibrotic gene expression in human renal mesangial cells,” American Journal Of Pathology, vol. 167, no. 3, pp. 683–694, 2005. View at Publisher · View at Google Scholar
  • Kr Schmelzer, L Kubala, Jw Newman, Ih Kim, Jp Eiserich, and Bd Hammock, “Soluble epoxide hydrolase is a therapeutic target for acute inflammation,” Proceedings Of The National Academy Of Sciences Of The United States Of Ame, vol. 102, no. 28, pp. 9772–9777, 2005. View at Publisher · View at Google Scholar
  • Rj Flower, and M Perretti, “Controlling inflammation: a fat chance?,” Journal Of Experimental Medicine, vol. 201, no. 5, pp. 671–674, 2005. View at Publisher · View at Google Scholar
  • Xibin Liang, Liejun Wu, Tracey Hand, and Katrin Andreasson, “Prostaglandin D2 mediates neuronal protection via the DP1 receptor,” Journal of Neurochemistry, vol. 92, no. 3, pp. 477–486, 2005. View at Publisher · View at Google Scholar
  • N Leitinger, and A Kadl, “The role of endothelial cells in the resolution of acute inflammation,” Antioxidants & Redox Signaling, vol. 7, no. 11-12, pp. 1744–1754, 2005. View at Publisher · View at Google Scholar
  • Otylia Kowal-Bielecka, Krzysztof Kowal, Oliver Distler, Joanna Rojewska, Anna Bodzenta-Lukaszyk, Beat A. Michel, Renate E. Gay, Steffen Gay, and Stanislaw Sierakowski, “Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: An imbalance between proinflammatory and antiinflammatory lipid mediators,” Arthritis & Rheumatism, vol. 52, no. 12, pp. 3783–3791, 2005. View at Publisher · View at Google Scholar
  • John L. Wallace, “COX-2: A pivotal enzyme in mucosal protection and resolution of inflammation,” Thescientificworldjournal, vol. 6, pp. 577–588, 2006. View at Publisher · View at Google Scholar
  • Mj Mangino, L Brounts, B Harms, and C Heise, “Lipoxin biosynthesis in inflammatory bowel disease,” Prostaglandins & Other Lipid Mediators, vol. 79, no. 1-2, pp. 84–92, 2006. View at Publisher · View at Google Scholar
  • Fumiaki Kojima, Mohit Kapoor, Shinichi Kawai, and Leslie J Crofford, “New insights into eicosanoid biosynthetic pathways: implications for arthritis,” Expert Review of Clinical Immunology, vol. 2, no. 2, pp. 277–291, 2006. View at Publisher · View at Google Scholar
  • Michael Scannell, and Paola Maderna, “Lipoxins and annexin-1: Resolution of inflammation and regulation of phagocytosis of apoptotic cells,” Thescientificworldjournal, vol. 6, pp. 1555–1573, 2006. View at Publisher · View at Google Scholar
  • Fayez Kotob, and Mark J. Lema, “Nonopioid Analgesics,” Cancer Pain, pp. 253–303, 2006. View at Publisher · View at Google Scholar
  • Hendrik Schultz, and Jerrold P. Weiss, “The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease,” Clinica Chimica Acta, vol. 384, no. 1-2, pp. 12–23, 2007. View at Publisher · View at Google Scholar
  • O. Yasuda, Y. Takemura, H. Kawamoto, and H. Rakugi, “Aspirin: recent developments,” Cellular And Molecular Life Sciences, vol. 65, no. 3, pp. 354–358, 2008. View at Publisher · View at Google Scholar
  • Md. Jahurul Karim, Parimal Bhattacherjee, Sumana Biswas, and Christopher A. Paterson, “Anti-Inflammatory Effects of Lipoxins on Lipopolysaccharide-Induced Uveitis in Rats,” Journal Of Ocular Pharmacology And Therapeutics, vol. 25, no. 6, pp. 483–486, 2009. View at Publisher · View at Google Scholar
  • Carmen M. Navarrete, Moisés Pérez, Amaya García de Vinuesa, Juan A. Collado, Bernd L. Fiebich, Marco A. Calzado, and Eduardo Muñoz, “Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway,” Biochemical Pharmacology, vol. 79, no. 12, pp. 1805–1814, 2010. View at Publisher · View at Google Scholar
  • Gerard L. Bannenberg, “Therapeutic Applicability of Anti-Inflammatory and Proresolving Polyunsaturated Fatty Acid-Derived Lipid Mediators,” Thescientificworldjournal, vol. 10, pp. 676–712, 2010. View at Publisher · View at Google Scholar
  • Elvira L. Liclican, and Karsten Gronert, “Molecular Circuits of Resolution in the Eye,” Thescientificworldjournal, vol. 10, pp. 1029–1047, 2010. View at Publisher · View at Google Scholar
  • Emma Boergeson, and Catherine Godson, “Molecular Circuits of Resolution in Renal Disease,” Thescientificworldjournal, vol. 10, pp. 1370–1385, 2010. View at Publisher · View at Google Scholar
  • Charles N. Serhan, “Lipoxins and Aspirin-Triggered 15-epi-Lipoxins,” Handbook of Cell Signaling, pp. 1235–1242, 2010. View at Publisher · View at Google Scholar
  • J. W. Mercante, R. M. Jones, and A. S. Neish, “Reactive Oxygen Production Induced by the Gut Microbiota: Pharmacotherapeutic Implications,” Current Medicinal Chemistry, vol. 19, no. 10, pp. 1519–1529, 2012. View at Publisher · View at Google Scholar
  • Stephanie Georgina Dakin, Dirk Werling, Andrew Hibbert, Dilkush Robert Ephrem Abayasekara, Natalie Jayne Young, Roger Kenneth Whealands Smith, and Jayesh Dudhia, “Macrophage Sub-Populations and the Lipoxin A(4) Receptor Implicate Active Inflammation during Equine Tendon Repair,” Plos One, vol. 7, no. 2, 2012. View at Publisher · View at Google Scholar
  • Stephanie Georgina Dakin, Jayesh Dudhia, Natalie Jayne Werling, Dirk Werling, Dilkush Robert Ephrem Abayasekara, and Roger Kenneth Whealands Smith, “Inflamm-Aging and Arachadonic Acid Metabolite Differences with Stage of Tendon Disease,” Plos One, vol. 7, no. 11, 2012. View at Publisher · View at Google Scholar
  • Marcelo O. Freire, and Thomas E. Van Dyke, “Natural resolution of inflammation,” Periodontology 2000, vol. 63, no. 1, pp. 149–164, 2013. View at Publisher · View at Google Scholar
  • S. G. Dakin, J. Dudhia, and R. K. W. Smith, “Science in brief: Resolving tendon inflammation. A new perspective,” Equine Veterinary Journal, vol. 45, no. 4, pp. 398–400, 2013. View at Publisher · View at Google Scholar
  • B. Wu, J.A. Walker, D. Temmermand, K. Mian, B. Spur, A. Rodriguez, T.P. Stein, P. Banerjee, and K. Yin, “Lipoxin A4 promotes more complete inflammation resolution in sepsis compared to stable lipoxin A4 analog,” Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2013. View at Publisher · View at Google Scholar
  • Ravinder Kodela, Mitali Chattopadhyay, Satindra Goswami, Zong Yuan Gan, Praveen P. N. Rao, Kamran V. Nia, Carlos A. Velazquez-Martinez, and Khosrow Kashfi, “Positional Isomers of Aspirin Are Equally Potent in Inhibiting Colon Cancer Cell Growth: Differences in Mode of Cyclooxygenase Inhibition,” Journal Of Pharmacology And Experimental Therapeutics, vol. 345, no. 1, pp. 85–94, 2013. View at Publisher · View at Google Scholar
  • R. Braun-Dullaeus, A. Gardemann, and F. Meyer, “What the Surgeon Needs to Know about Basic New Concepts of Inflammation and their Therapeutic Consequences: Sanitation of Inflammation is not a Passive but rather an Active Process Regulated by Lipid Mediators,” Zentralblatt Fur Chirurgie, vol. 138, no. 3, pp. 322–330, 2013. View at Publisher · View at Google Scholar
  • Zhi-Fu Wang, Qian Li, Shen-Bin Liu, Wen-Li Mi, Shan Hu, Jing Zhao, Yu Tian, Qi-Liang Mao-Ying, Jian-Wei Jiang, Hong-Jian Ma, Yan-Qing Wang, and Gen-Cheng Wu, “Aspirin-triggered LipoxinA4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats,” Neuroscience, 2014. View at Publisher · View at Google Scholar
  • Mary S. McCarthy, Brian B. Morgan, John T. Heineman, and Robert G. Martindale, “Nutritional Armor for the Injured Warfighter: Omega-3 Fatty Acids in Surgery, Trauma, and Intensive Care,” Military Medicine, vol. 179, no. 11, pp. 88–94, 2014. View at Publisher · View at Google Scholar
  • J. David Lambeth, and Andrew S. Neish, “Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited,” Annual Review of Pathology: Mechanisms of Disease, vol. 9, no. 1, pp. 119–145, 2014. View at Publisher · View at Google Scholar
  • S. G. Dakin, F. O. Martinez, C. Yapp, G. Wells, U. Oppermann, B. J. F. Dean, R. D. J. Smith, K. Wheway, B. Watkins, L. Roche, and A. J. Carr, “Inflammation activation and resolution in human tendon disease,” Science Translational Medicine, vol. 7, no. 311, pp. 311ra173–311ra173, 2015. View at Publisher · View at Google Scholar
  • S. G. Dakin, “A review of the healing processes in equine superficial digital flexor tendinopathy,” Equine Veterinary Education, 2016. View at Publisher · View at Google Scholar
  • Marcelo O. Freire, Jesmond Dalli, Charles N. Serhan, and Thomas E. Van Dyke, “Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes,” The Journal of Immunology, vol. 198, no. 2, pp. 718–728, 2016. View at Publisher · View at Google Scholar
  • S. Sodin-Semrl, A. Spagnolo, R. Mikus, B. Barbaro, J. Varga, and S. Fiore, “Opposing Regulation of Interleukin-8 and NF-kB Responses by Lipoxin A4 and Serum Amyloid a via the Common Lipoxin a Receptor,” International Journal of Immunopathology and Pharmacology, vol. 17, no. 2, pp. 145–155, 2017. View at Publisher · View at Google Scholar
  • Maria G. Balta, Bruno G. Loos, and Elena A. Nicu, “Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Robert A. Whittington, Emmanuel Planel, and Niccolò Terrando, “Impaired Resolution of Inflammation in Alzheimer’s Disease: A Review,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • James Trauer, Stephen Muhi, Emma S. McBryde, Shmeylan A. Al Harbi, Yaseen M. Arabi, Andrew J. Boyle, Rodrigo Cartin-Ceba, Wei Chen, Yung-Tai Chen, Marco Falcone, Ognjen Gajic, Jack Godsell, Michelle Ng Gong, Daryl Kor, Wolfgang Lösche, Daniel F. McAuley, Hollis R. O’Neal, Michael Osthoff, Gordon P. Otto, Maik Sossdorf, Min-Juei Tsai, Juan C. Valerio-Rojas, Tom van der Poll, Francesco Violi, Lorraine Ware, Andreas F. Widmer, Maryse A. Wiewel, Johannes Winning, and Damon P. Eisen, “Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths,” Critical Care Medicine, vol. 45, no. 11, pp. 1871–1879, 2017. View at Publisher · View at Google Scholar
  • Ping Duan, Yong Liu, and Jiawen Li, “The comparative efficacy and safety of topical non-steroidal anti-inflammatory drugs for the treatment of anterior chamber inflammation after cataract surgery: a systematic review and network meta-analysis,” Graefe's Archive for Clinical and Experimental Ophthalmology, 2017. View at Publisher · View at Google Scholar
  • Malvina Hoxha, “A systematic review on the role of eicosanoid pathways in rheumatoid arthritis,” Advances in Medical Sciences, vol. 63, no. 1, pp. 22–29, 2018. View at Publisher · View at Google Scholar