The Scientific World Journal

The Scientific World Journal / 2004 / Article

Review Article | Open Access

Volume 4 |Article ID 913841 |

Margaret Tzaphlidou, "Collagenous Tissues upon Lithium Treatment: A Quantitative Ultrastructural Study", The Scientific World Journal, vol. 4, Article ID 913841, 17 pages, 2004.

Collagenous Tissues upon Lithium Treatment: A Quantitative Ultrastructural Study

Received19 May 2004
Revised02 Aug 2004
Accepted02 Aug 2004


In this review, the influence of lithium treatment in mouse, rat, and rabbit skin, liver, bone, and aorta, as well as arachnoid and dura mater collagen fibrils, is examined using electron microscopy and image processing. Structural changes (fibril architecture and diameter) are detected at the ultrastructural level in specimens from all lithium-treated tissues. The overall collagen fibril architecture is disturbed as compared with specimens from normal species. The mean diameter values of treated collagen fibrils are significantly smaller than those from controls in all tissues examined. The banding patterns of fibrils are normal in all cases. Measurements by a computerized method of measuring axial periodicity of fibrils indicate no effect of lithium on this parameter. Computer analysis shows no differences in charged amino acid composition between lithium-treated and -untreated samples. Under the present experimental conditions, lithium can induce permanent structural collagen alterations.

More related articles

 PDF Download Citation Citation
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.