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Volume 5, Pages 828-833
Review Article

The Diagnosis of Minimal Change Disease in Diabetic Nephropathy

Department of Pathology, Renal Pathology Laboratory, VC14-224, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA

Received 10 August 2005; Revised 24 September 2005; Accepted 26 September 2005

Copyright © 2005 M. Barry¬†Stokes.


Proteinuria is common in diabetic patients and usually reflects the presence of diabetic glomerulosclerosis. This paper reviews the differential diagnosis of proteinuria in diabetic patients and discusses the role of renal biopsy examination in identification and management of minimal change disease in this cohort. Identification of nondiabetic glomerular disease requires careful correlation of clinical history and renal biopsy findings and may have important implications for prognosis and therapy.