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Volume 5, Pages 5-8
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Combined Effects of Estrogen and Mechanical Loading on Anterior Cruciate Ligament Fibroblast Biosynthesis

Sports Medicine Research Center, Department of Orthopedic Surgery, Baylor College of Medicine, 6550 Fannin Street, Suite 451, Houston, TX 77030, USA

Received 9 December 2004; Revised 14 December 2004; Accepted 14 January 2005

Copyright © 2005 Xuhui Liu and Zong-Ping Luo.


For some time, estrogen has been suspected to play a negative role in anterior cruciate ligament (ACL) fibroblast biosynthesis; however, reports on this issue have been controversial. In a recent study, our group demonstrated a negative combined effect of estrogen and mechanical loading on the gene expression of major extracellular matrix component molecules in ACL fibroblasts.