The Scientific World Journal

The Scientific World Journal / 2006 / Article

Mini-Review Article | Open Access

Volume 6 |Article ID 148153 | https://doi.org/10.1100/tsw.2006.133

Donald L. Yee, "Platelets as Modifiers of Clinical Phenotype in Hemophilia", The Scientific World Journal, vol. 6, Article ID 148153, 8 pages, 2006. https://doi.org/10.1100/tsw.2006.133

Platelets as Modifiers of Clinical Phenotype in Hemophilia

Academic Editor: James N. George
Received10 Apr 2006
Accepted24 May 2006

Abstract

Platelets occupy a central role in the maintenance of hemostasis by adhering to sites of vascular injury and facilitating thrombin generation, which leads to the formation of a fibrin clot. Patients with hemophilia exhibit defective thrombin generation secondary to reduced plasma factor concentrations, which can lead to excessive and sometimes life-threatening bleeding. Individuals differ greatly with respect to platelet function and platelets from different individuals differ inherently in their ability to enact thrombin generation, the key coagulative process that is deficient in hemophilia. Similarly, some patients with hemophilia seem to bleed less often than others despite exhibiting similar plasma factor levels. The biologic factors that underlie this phenotypic variability remain poorly understood, but evidence is reviewed supporting a role for platelets and platelet-related factors in modifying bleeding tendency in patients with hemophilia and potential directions for further clinical research in this area are discussed.


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