The Scientific World Journal

The Scientific World Journal / 2006 / Article

Mini-Review Article | Open Access

Volume 6 |Article ID 216841 | https://doi.org/10.1100/tsw.2006.162

Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai, "Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties", The Scientific World Journal, vol. 6, Article ID 216841, 10 pages, 2006. https://doi.org/10.1100/tsw.2006.162

Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties

Academic Editor: Frank S. Walsh
Received28 Jan 2006
Revised04 May 2006
Accepted27 Jun 2006

Abstract

Despite the progress of the bioinformatics approach to characterize cell-surface antigens and receptors on tumor cells, it remains difficult to generate novel cancer vaccines or neutralizing monoclonal antibody therapeutics. Among targeted cancer therapeutics, biologicals with targetable antibodies or ligands conjugated or fused to toxins or chemicals for direct cell-killing ability have been developed over the last 2 decades. These conjugated or fused chimeric proteins are termed immunotoxins or cytotoxic agents. Two agents, DAB389IL-2 (ONTAKTM) targeting the interleukin-2 receptor and CD33-calicheamicin (Mylotarg®), have been approved by the FDA for cutaneous T-cell lymphoma (CTCL) and relapsed acute myeloid leukemia (AML), respectively. Such targetable agents, including RFB4(dsFv)-PE38 (BL22), IL13-PE38QQR, and Tf-CRM107, are being tested in clinical trials. Several agents using unique technology such as a cleavable adapter or immunoliposomes with antibodies are also in the preclinical stage. This review summarizes the generation, mechanism, and development of these agents. In addition, possible future directions of this therapeutic approach are discussed.


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