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TheScientificWorldJOURNAL
Volume 6 (2006), Pages 2411-2419
http://dx.doi.org/10.1100/tsw.2006.374
Research Article

Papillary and Nonpapillary Calcium Oxalate Monohydrate Renal Calculi: Comparative Study of Etiologic Factors

1University Hospital Son Dureta, C/ Andrea Doria 55, E07014-Palma de Mallorca, Spain
2Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research, University of Illes Balears, Ctra. Valldemossa km 7.5, E07122-Palma de Mallorca, Spain

Received 6 February 2006; Revised 7 April 2006; Accepted 11 April 2006

Academic Editor: Ziya Kirkali

Copyright © 2006 Enrique Pieras et al.

Abstract

Calcium oxalate monohydrate (COM) renal calculi can be classified into two groups: papillary and nonpapillary. In this paper, a comparative study between etiologic factors of COM papillary and nonpapillary calculi is performed. The study included 40 patients with COM renal calculi. The urine of these individuals was analyzed. Case history, lifestyle, and dietetic habits were obtained.No significant differences between urinary biochemical data of both groups were observed; 50% of COM papillary stone formers and 40% of COM nonpapillary stone formers had urolithiasis family history. A low consumption of phytate-rich products was observed for both groups. A relationship between profession with occupational exposure to cytotoxic products and COM papillary renal lithiasis was detected.The results suggest that COM papillary calculi would be associated to papillary epithelium alterations together with a crystallization inhibitors deficit, whereas COM nonpapillary calculi would be associated to the presence of heterogeneous nucleants and a crystallization inhibitors deficit.