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Volume 6, Pages 1851-1861
Review Article

Chromatin Modification and Remodeling in Heart Development

1Programmes in Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, Toronto, ON, Canada
2The Heart and Stroke/Richard Lewar Centre of Excellence at the University of Toronto, Toronto, ON, M5S 1A8, Canada
3Department of Molecular & Medical Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada

Received 17 January 2006; Revised 3 April 2006; Accepted 6 April 2006

Academic Editor: Michael K. Richardson

Copyright © 2006 Paul Delgado-Olguín et al.


In organogenesis, cell types are specified from determined precursors as morphogenetic patterning takes place. These events are largely controlled by tissue-specific transcription factors. These transcription factors must function within the context of chromatin to activate or repress target genes. Recent evidence suggests that chromatin-remodeling and -modifying factors may have tissue-specific function. Here we review the potential roles for chromatin-remodeling and -modifying proteins in the development of the mammalian heart.