The Scientific World Journal

The Scientific World Journal / 2007 / Article
Special Issue

Eicosanoid Receptors and Inflammation

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Review Article | Open Access

Volume 7 |Article ID 174754 | https://doi.org/10.1100/tsw.2007.187

Magnus Bäck, "Leukotriene Receptors: Crucial Components in Vascular Inflammation", The Scientific World Journal, vol. 7, Article ID 174754, 18 pages, 2007. https://doi.org/10.1100/tsw.2007.187

Leukotriene Receptors: Crucial Components in Vascular Inflammation

Academic Editor: Charles Brink
Received22 Jan 2007
Revised18 Jun 2007
Accepted02 Jul 2007

Abstract

The accumulation of immune cells during vascular inflammation leads to formation of leukotrienes (LTs). While macrophages represent a major source of LT biosynthesis in the proximity of the vascular wall, activated T lymphocytes may, in addition, play a key regulatory role on macrophage expression of LT-forming enzymes. Within the vascular wall, LTs activate cell surface receptors of the BLT and CysLT subtypes expressed on vascular smooth muscle and endothelial cells. The LT receptor expression on those cells is highly dependent on transcriptional regulation by pro- and anti-inflammatory mediators. LT receptor activation on vascular smooth muscle cells is associated with both directly and indirectly induced vasoconstriction, as well as intimal hyperplasia through stimulation of migration and proliferation. On the other hand, endothelial LT receptors induce vasorelaxation and leukocyte recruitment and adhesion. Results from in vitro and in vivo studies of LT receptor antagonists indicate potential beneficial effects in atherosclerosis and other inflammatory cardiovascular diseases.


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