The Scientific World Journal

The Scientific World Journal / 2007 / Article
Special Issue

Eicosanoid Receptors and Inflammation

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Review Article | Open Access

Volume 7 |Article ID 391483 | https://doi.org/10.1100/tsw.2007.180

Thomas G. Brock, Marc Peters-Golden, "Activation and Regulation of Cellular Eicosanoid Biosynthesis", The Scientific World Journal, vol. 7, Article ID 391483, 12 pages, 2007. https://doi.org/10.1100/tsw.2007.180

Activation and Regulation of Cellular Eicosanoid Biosynthesis

Academic Editor: Charles Brink
Received22 Jan 2007
Revised29 May 2007
Accepted02 Jul 2007

Abstract

There is a growing appreciation for the wide variety of physiological responses that are regulated by lipid messengers. One particular group of lipid messengers, the eicosanoids, plays a central role in regulating immune and inflammatory responses in a receptor-mediated fashion. These mediators are related in that they are all derived from one polyunsaturated fatty acid, arachidonic acid. However, the various eicosanoids are synthesized by a wide variety of cell types by distinct enzymatic pathways, and have diverse roles in immunity and inflammation. In this review, the major pathways involved in the synthesis of eicosanoids, as well as key points of regulation, are presented.


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